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Differences of the lamina cribrosa between primary open angle glaucoma and non-pathologic high myopia
Qing-Qing Mu1,2, Ping Ge1,2, Xu Liu1
1Department of Ophthalmology, the Second Affiliated Hospital of Xi'an Medical University, Xi'an 710038, Shaanxi Province, China.
International Journal of Ophthalmology
|May 29, 2026
Summary
Primary open angle glaucoma (POAG) and high myopia (HM) share structural changes in the lamina cribrosa (LC). Understanding these changes in POAG and HM can help detect and treat optic nerve damage.
Area of Science:
- Ophthalmology
- Neuroscience
- Pathology
Background:
- Primary open angle glaucoma (POAG) is a leading cause of irreversible blindness.
- Retinal ganglion cell (RGC) degeneration characterizes POAG.
- Global population aging increases POAG incidence and blindness prevalence.
Purpose of the Study:
- To review and compare pathological alterations of the lamina cribrosa (LC) in POAG and high myopia (HM).
- To clarify the LC's role in optic nerve damage initiation and progression in both conditions.
- To identify structural similarities and differences between POAG and HM in the LC.
Main Methods:
- Literature review of studies on POAG and HM pathology.
- Comparative analysis of structural changes in the lamina cribrosa.
- Synthesis of findings on optic nerve injury mechanisms.
Main Results:
- POAG and non-pathologic HM exhibit similar early-stage structural changes in the LC.
- Distinct pathological alterations in the LC may exist between POAG and HM.
- The LC is implicated in the early phases of optic nerve injury in both conditions.
Conclusions:
- The lamina cribrosa plays a critical role in optic nerve damage in both POAG and HM.
- Elucidating LC alterations can aid in early detection of at-risk individuals.
- Structural insights may lead to targeted interventions for preventing vision loss.
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