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Related Experiment Video

Updated: May 31, 2026

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans

Published on: December 18, 2016

Soft tissue changes in Dementia: A comprehensive systematic review.

Francesco Pipitone^1,2, Caterina Bernetti^1,2, Gianfranco Di Gennaro³

¹Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.

|May 29, 2026

Summary

This summary is machine-generated.

Temporomandibular joint (TMJ) imaging can identify sarcopenia, a condition linked to dementia. Muscle loss and fat infiltration in the face correlate with cognitive decline and brain atrophy in Alzheimer's disease and dementia with Lewy bodies.

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Last Updated: May 31, 2026

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans

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Published on: December 18, 2016

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

Area of Science:

Neurology
Gerontology
Biomarkers

Background:

Sarcopenia, characterized by muscle loss, is increasingly recognized as a systemic condition.
Dementia, including Alzheimer's disease (AD) and dementia with Lewy bodies (DLB), is a growing public health concern.
The relationship between sarcopenia and cognitive decline requires further investigation, particularly in imaging biomarkers.

Purpose of the Study:

To investigate temporomandibular joint (TMJ) imaging as a potential biomarker for sarcopenia in dementia.
To explore the correlation between craniofacial muscle characteristics and cognitive impairment.
To examine the association between muscle fat infiltration and brain atrophy in AD and DLB.

Main Methods:

Utilized TMJ imaging techniques to assess craniofacial muscle mass and fat infiltration.
Correlated imaging findings with cognitive assessment scores.
Analyzed brain volumes and atrophy patterns in participants with AD and DLB.

Main Results:

TMJ imaging proved to be a viable method for identifying sarcopenia in dementia patients.
Craniofacial muscle loss significantly correlated with cognitive impairment.
Increased muscle fat infiltration was linked to greater brain atrophy in both AD and DLB.

Conclusions:

Sarcopenia is a relevant factor in dementia, potentially detectable through craniofacial muscle imaging.
Shared metabolic and inflammatory pathways may underlie the connection between sarcopenia and dementia.
TMJ imaging offers a novel, non-invasive approach to assessing sarcopenia in the context of cognitive decline.