Related Experiment Video

Updated: May 31, 2026

Robot-Assisted Laparoscopic Splenectomy In Children: A Case Report with Literature Review
05:06

Robot-Assisted Laparoscopic Splenectomy In Children: A Case Report with Literature Review

Published on: March 27, 2026

Perioperative Prophylaxis in Pediatric Factor VII Deficiency: Experience From Rabat Children's Hospital

Chaymaa El Messari1, Zineb Isfaoun1, Naoual El Ansari1

  • 1Hemophilia and Inherited Bleeding Disorders Treatment Center, Pediatric Hematology and Oncology Center, Ibn Sina University Hospital Center, Mohammed V University, Rabat, MAR.

Cureus
|May 29, 2026
PubMed

Insights

Perioperative prophylaxis with recombinant activated factor VII (rFVIIa) is effective for managing children with factor VII deficiency undergoing surgery. A single dose showed favorable hemostatic outcomes, minimizing bleeding risks in this rare bleeding disorder.

Area of Science:

  • Pediatric Hematology
  • Hemostasis and Thrombosis
  • Rare Bleeding Disorders

Background:

  • Factor VII (FVII) deficiency is a rare inherited bleeding disorder with unpredictable bleeding risks.
  • Children with FVII deficiency face significant perioperative bleeding risks during surgery.
  • Effective prophylactic management is crucial for surgical safety in these patients.

Purpose of the Study:

  • To evaluate postoperative hemostatic outcomes in children with FVII deficiency.
  • To assess hemorrhagic complications based on surgical type and perioperative prophylaxis.
  • To determine the efficacy of prophylaxis in managing FVII deficiency during surgical procedures.

Main Methods:

  • Retrospective review of medical records for pediatric patients with confirmed FVII deficiency undergoing surgery.
  • Data collection included patient demographics, FVII activity levels, surgical procedures, and perioperative prophylaxis used.
  • Postoperative outcomes, including bleeding events and complications, were analyzed.

Main Results:

  • Eight children (ages 4-6) with FVII deficiency underwent various procedures (e.g., tonsillectomy, dental extractions).
  • Recombinant activated factor VII (rFVIIa) prophylaxis (30 µg/kg) was primarily used, with one patient receiving fresh frozen plasma (FFP).
  • Minimal postoperative bleeding was observed; one FFP-treated patient had a scrotal hematoma, and no thrombotic events occurred.

Conclusions:

  • Perioperative rFVIIa prophylaxis demonstrated favorable hemostatic outcomes in pediatric FVII deficiency patients undergoing surgery.
  • A single preoperative dose of rFVIIa may be sufficient for minor procedures.
  • Larger studies are needed to confirm these findings due to the small sample size (n=8).
Abstract

Keywords:
bleeding disordersfactor vii deficiencyhemostasispediatric surgeryperioperative prophylaxisrecombinant activated factor vii

More Related Videos

Tail Vein Transection Bleeding Model in Fully Anesthetized Hemophilia A Mice08:13

Tail Vein Transection Bleeding Model in Fully Anesthetized Hemophilia A Mice

Published on: September 30, 2021

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...