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05:44
Skin Biopsy for Diagnosing Discoid Lupus Erythematosus
Published on: June 10, 2025
Bullous Systemic Lupus Erythematosus: Clinical Presentation in Two Asian Cases
Phuong Thi Thanh Nguyen1, Thuy Thi Phan Nguyen1,2, Hoang Vu Nguyen3
1Clinial Trial Unit, Ho Chi Minh City Hospital of Dermato-Venereology, Ho Chi Minh City, Vietnam.
Case Reports in Medicine
|May 29, 2026
Summary
Bullous systemic lupus erythematosus (BSLE), a rare form of systemic lupus erythematosus (SLE), presents with blistering skin lesions. This report details two Vietnamese cases, highlighting diagnostic considerations for this uncommon condition.
Area of Science:
- Dermatology
- Rheumatology
- Immunology
Background:
- Bullous systemic lupus erythematosus (BSLE) is a rare variant of systemic lupus erythematosus (SLE).
- It is characterized by vesiculobullous lesions on sun-exposed skin.
- BSLE can be a presenting feature or occur in patients with established SLE.
Purpose of the Study:
- To report two cases of BSLE diagnosed in Vietnam.
- To emphasize the diagnostic challenges and clinical features of BSLE.
- To contribute to the understanding of BSLE in diverse geographic settings.
Main Methods:
- Clinical case presentation.
- Review of diagnostic criteria for BSLE.
- Inclusion of immunofluorescence, histology, and serology.
Main Results:
- Two cases of BSLE were identified and managed.
- The cases illustrate the varied presentation of BSLE.
- Diagnostic workup confirmed BSLE in both patients.
Conclusions:
- BSLE requires careful clinical and laboratory evaluation for accurate diagnosis.
- Early recognition is crucial for appropriate management.
- Further case reports are valuable for understanding BSLE prevalence and presentation.
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