Bullous Systemic Lupus Erythematosus: Clinical Presentation in Two Asian Cases

Bullous systemic lupus erythematosus (BSLE) is a rare subset of systemic lupus erythematosus (SLE), characterized by the rapid onset of vesiculobullous lesions that primarily affect sun-exposed areas of the body. These lesions typically form along the dermal-epidermal junction and are associated with the presence of autoantibodies that target the skin. While BSLE often occurs in patients with a prior diagnosis of SLE, it can occasionally present as the initial manifestation of the disease. The diagnosis of BSLE requires a thorough evaluation based on clinical features, immunofluorescence studies, histological findings, and serological testing to distinguish it from other similar dermatological conditions. Herein, we report two cases of BSLE at a tertiary Dermatology Hospital in Vietnam.