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Related Experiment Video

Updated: May 31, 2026

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
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Effect of Pulsed Radiofrequency with Various Time-Course on Rheumatoid Arthritis Joint Pain in Rats.

Xin Li1,2, Meng Wang2, YingDi Wang2

  • 1Department of Clinical Medical College, Yangzhou University, Yangzhou, 225001, People's Republic of China.

Journal of Pain Research
|May 29, 2026
PubMed
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This summary is machine-generated.

Pulsed radiofrequency (PRF) treatment for rheumatoid arthritis (RA) in rats effectively reduced joint pain and inflammation. Longer PRF durations (2-3 minutes) showed superior results in mitigating joint damage and inflammatory markers.

Area of Science:

  • Rheumatology
  • Pain Management
  • Biomedical Engineering

Background:

  • Rheumatoid arthritis (RA) is a chronic autoimmune disease causing joint inflammation and damage.
  • Current RA treatments may have limitations, necessitating exploration of novel therapeutic modalities.
  • Pulsed radiofrequency (PRF) is an emerging technique for pain management with potential anti-inflammatory effects.

Purpose of the Study:

  • To investigate the efficacy of pulsed radiofrequency (PRF) treatment with varying durations on joint pain and pathological damage in a rat model of rheumatoid arthritis (RA).
  • To assess the impact of PRF on inflammatory markers and specific ion channel expression in RA-affected joints.

Main Methods:

  • An RA model was induced in Sprague-Dawley rats using type II collagen.
Keywords:
TRPA1TRPV1joint damagepulsed radiofrequencyrheumatoid arthritis

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  • Dorsal root ganglia (DRG) were stimulated with PRF for 1, 2, or 3 minutes.
  • Joint diameter, cartilage pathology (Mankin and OARSI scores), inflammatory cytokines (TNF-α, IL-6, IL-1β), cell proliferation marker (Ki67), and ion channels (TRPA1, TRPV1) were evaluated.

    • Main Results:

    • PRF treatment, particularly for 2 and 3 minutes, significantly reduced joint damage and pathological scores compared to the RA group.
    • PRF therapy led to decreased levels of TNF-α, IL-1β, and IL-6 in peripheral blood.
    • Reduced Ki67 expression and lower levels of TRPA1 and TRPV1 were observed in the synovial tissues of PRF-treated rats.

    Conclusions:

    • Pulsed radiofrequency (PRF) treatment effectively ameliorates joint damage in a rat model of rheumatoid arthritis (RA).
    • The therapeutic effects of PRF appear to be linked to the inhibition of joint inflammation and modulation of specific pain-related ion channels.