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Updated: May 31, 2026

Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults
Published on: April 22, 2022
Body composition in adults with phenylketonuria: A 5 years follow-up study
Bianca Fasolo Franceschetto1,2,3, Yannick Moutapam-Ngamby-Adriaansen2,3, Nathalie Tressel2
1Federal University of Rio Grande do Sul - Postgraduate Program in Medicine: Medical Sciences, Porto Alegre, RS, Brazil.
None:
This longitudinal study evaluated body composition in 24 early-treated adults with PKU using Dual-Energy X-ray Absorptiometry (DXA). At baseline, eutrophy, overweight, and obesity were found in 9, 9, and 6 patients, respectively. After 5 years, sixteen patients presented reduction in lean mass and an increase in body fat percentage, despite stable weight and BMI. These adverse changes may be linked to the phenylalanine restricted diet. These findings highlight the need for monitoring and targeted interventions to mitigate body composition deterioration in this population.
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