Related Experiment Video

Updated: May 31, 2026

In Vivo Electrophysiological Measurement of Compound Muscle Action Potential from the Forelimbs in Mouse Models of Motor Neuron Degeneration
06:35

In Vivo Electrophysiological Measurement of Compound Muscle Action Potential from the Forelimbs in Mouse Models of Motor Neuron Degeneration

Published on: June 15, 2018

Reply to: Mathematical Comments on Linking Neurofilament Light Chain Levels to Disease Severity in Hereditary Spastic

Habibah A P Agianda1,2, Darius Ebrahimi-Fakhari1,2

  • 1Movement Disorders Program, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Movement Disorders : Official Journal of the Movement Disorder Society
|May 29, 2026
PubMed
Abstract

No abstract available in PubMed .

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Alterations in muscle tone are common manifestations of neurological disorders and reflect dysfunction within different nervous system regions. Spasticity, paratonia, and dystonia represent distinct forms of hypertonia, each with unique mechanisms, clinical features, and diagnostic importance.CharacteristicsSpasticity happens from upper motor neuron lesions and is characterized by velocity-dependent resistance to passive movement. Clinical features include:Exaggerated deep tendon reflexesClonus...