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Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...

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Related Experiment Video

Updated: May 31, 2026

Constructing a Collagen Hydrogel for the Delivery of Stem Cell-loaded Chitosan Microspheres

Constructing a Collagen Hydrogel for the Delivery of Stem Cell-loaded Chitosan Microspheres

Published on: June 1, 2012

"Multipurpose" Gelatin-Chitosan-Based Injectable Gel Platform for Stem Cell Expansion, Delivery, and Tissue

Priyanka Surya¹, Sarika Tomar¹, Kirti Chopra¹

¹Regenerative Biology Research Lab, Department of Clinical Research and Medical Management, Institute of Nuclear Medicine and Allied Sciences, Brig. S. K. Mazumdar Road, Delhi 110054, India.

Biomacromolecules

|May 29, 2026

Summary

Gelatin-chitosan microspheres act as a dual-delivery platform for cells and growth factors, enhancing 3D cell expansion and transplantation. This biomimetic system promotes stem cell differentiation and survival for regenerative medicine applications.

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Last Updated: May 31, 2026

Constructing a Collagen Hydrogel for the Delivery of Stem Cell-loaded Chitosan Microspheres

Constructing a Collagen Hydrogel for the Delivery of Stem Cell-loaded Chitosan Microspheres

Published on: June 1, 2012

Preparation of Chitosan-based Injectable Hydrogels and Its Application in 3D Cell Culture

Preparation of Chitosan-based Injectable Hydrogels and Its Application in 3D Cell Culture

Published on: September 29, 2017

Fabrication of Size-Controlled and Emulsion-Free Chitosan-Genipin Microgels for Tissue Engineering Applications

Fabrication of Size-Controlled and Emulsion-Free Chitosan-Genipin Microgels for Tissue Engineering Applications

Published on: April 13, 2022

Area of Science:

Biomaterials Science
Regenerative Medicine
Tissue Engineering

Background:

Microsphere-based 3D platforms offer biomimetic microenvironments for enhanced cell survival, proliferation, and functional integration.
These platforms are advantageous for cell expansion, targeted delivery, and transplantation.

Purpose of the Study:

To fabricate gelatin-chitosan microspheres as a dual-delivery platform for cells and growth factors.
To utilize these microspheres for 3D cell expansion and transplantation.
To investigate the sustained release of growth factors for stem cell differentiation.

Main Methods:

Fabrication of gelatin-chitosan microspheres.
Loading and culturing of mesenchymal stem cells and growth factors onto microspheres.
Second layer coating for cell protection during transplantation.
Assessment of sustained growth factor release and stem cell differentiation (osteogenic, adipogenic, chondrogenic).

Main Results:

Successful fabrication of gelatin-chitosan microspheres as a dual-delivery system.
Demonstrated ability for 3D cell expansion and harvesting.
Sustained release of growth factors promoting stem cell differentiation into multiple lineages.
Enhanced cell survival and functional integration due to the biomimetic microenvironment.

Conclusions:

Gelatin-chitosan microspheres provide a versatile 3D platform for cell expansion, delivery, and transplantation.
The dual-delivery system effectively supports stem cell differentiation and offers potential in regenerative medicine.
This approach enhances cell survival and integration, paving the way for advanced therapeutic strategies.