CBC-Derived Biomarkers Associated With Recurrence After Sinus Surgery in Chronic Rhinosinusitis

Area of Science:

• Otolaryngology
• Immunology
• Medical Biomarkers

Background:

• Chronic rhinosinusitis (CRS) frequently recurs after endoscopic sinus surgery (ESS).
• Limited biomarkers exist for predicting long-term recurrence risk in CRS patients.
• Complete blood count (CBC)-derived markers offer potential for risk stratification.

Purpose of the Study:

• To investigate the association between CBC-derived biomarkers and long-term CRS recurrence post-ESS.
• To evaluate the prognostic value of biomarkers like absolute eosinophil count (AEC) and systemic immune-inflammation index (SII).

Main Methods:

• Retrospective analysis of 543 CRS patients undergoing ESS.
• Time-to-event analysis using Cox regression with LASSO for variable selection.
• Assessment of CBC-derived biomarkers including AEC, SII, and various ratios.

Main Results:

• Higher baseline AEC and SII were independently associated with increased long-term CRS recurrence.
• AEC demonstrated significant incremental prognostic value, improving model discrimination.
• SII showed minimal additional predictive value beyond established clinical factors.

Conclusions:

• Elevated AEC and SII are linked to long-term CRS recurrence after ESS.
• AEC appears to be a more robust predictor of recurrence than SII.
• These biomarkers may indicate inherent host susceptibility rather than active disease processes.