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Updated: May 31, 2026

Analyzing Tumor and Tissue Distribution of Target Antigen Specific Therapeutic Antibody
07:36

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Published on: May 16, 2020

Evaluating Drug-Target Complexes in Therapeutic Monoclonal Antibodies Using A4F-MALS: Implications for Drug

Nina Liu1, Donald Kotowski1,2, Eric T Ong1

  • 1Product Biochemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA, regeneron.com.

Journal of Immunology Research
|May 29, 2026
PubMed
Summary

Characterizing immune complexes formed by therapeutic monoclonal antibodies (mAbs) is crucial. Asymmetric flow field-flow fractionation with multiangle light scattering (A4F-MALS) effectively analyzes these complexes, aiding drug development and clinical strategy.

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