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[Sepsis and septic shock - a comprehensive overview].

Michal Holub1, Ondřej Beran, Simona Arientová

  • 1Department of Infectious Diseases, 1st Faculty of Medicine, Charles University and Military University Hospital Prague,

Klinicka Mikrobiologie a Infekcni Lekarstvi
|May 29, 2026
PubMed
Summary
This summary is machine-generated.

Sepsis and septic shock are critical conditions causing high mortality. This review details their complex pathophysiology, diagnosis, and treatment, highlighting recent innovations for improved patient outcomes and reduced long-term morbidity.

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Last Updated: May 31, 2026

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
07:30

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Published on: June 15, 2019

A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats
05:56

A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats

Published on: February 20, 2021

Area of Science:

  • Critical Care Medicine
  • Immunology
  • Pathophysiology

Background:

  • Sepsis and septic shock are leading causes of in-hospital mortality.
  • These conditions significantly impact patient prognosis and survival rates.
  • Understanding the complex mechanisms is crucial for effective management.

Purpose of the Study:

  • To review current understanding of sepsis and septic shock pathophysiology.
  • To highlight recent advances and innovations in diagnosis and treatment.
  • To discuss the practical impact of these innovations on clinical care.

Main Methods:

  • Comprehensive literature review focusing on recent advancements.
  • Analysis of inflammatory and immune dysregulation in sepsis.
  • Examination of vascular endothelial damage and multiorgan dysfunction.

Main Results:

  • Sepsis involves complex inflammatory and immune dysregulation.
  • Vascular endothelial damage contributes to multiorgan dysfunction.
  • Recent innovations offer potential for improved sepsis management.

Conclusions:

  • Timely intervention and high-quality follow-up care are essential for septic patients.
  • Addressing the complexity of sepsis mechanisms can improve patient outcomes.
  • Continued research into sepsis pathophysiology is vital for reducing mortality and morbidity.