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Quantitative 161Tb SPECT/CT imaging for dosimetry using a ring-based digital CZT camera.

Eline Zoetelief1, Marcel Segbers2, Johannes Hofland3

  • 1Department of Radiology & Nuclear Medicine, Erasmus MC Cancer Institute, Rotterdam, 3015 CN, The Netherlands. e.zoetelief@erasmusmc.nl.

EJNMMI Physics
|May 29, 2026
PubMed
Summary
This summary is machine-generated.

This study shows that quantitative imaging of 161Terbium (161Tb) is feasible with CZT SPECT/CT systems. Optimized parameters yield higher recovery coefficients and better spatial resolution than 177Lutetium (177Lu), supporting 161Tb for radioligand therapy dosimetry.

Keywords:
Cadmium-zinc-telluride (CZT)Radioligand therapy (RLT)SPECT/CTStarGuideTerbium-161

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Area of Science:

  • Nuclear medicine
  • Medical imaging
  • Radiopharmaceutical therapy

Background:

  • 161Tb is a promising alternative to 177Lu for radioligand therapy (RLT).
  • Accurate dosimetry for RLT requires quantitative SPECT imaging.
  • Optimal reconstruction parameters for 161Tb on CZT SPECT/CT systems are not established.

Purpose of the Study:

  • To optimize 161Tb SPECT reconstruction parameters for a ring-based CZT digital SPECT/CT system.
  • To assess the feasibility of quantitative 161Tb imaging.

Main Methods:

  • Phantom study using NEMA imaging quality phantom with varying activity ratios.
  • Imaging on a StarGuide (GE Healthcare) ring-based CZT digital SPECT/CT system up to 2.2 GBq.
  • Evaluation of OSEM, Q.Clear (non-regularized and regularized) reconstruction methods with varying iterations/subsets.
  • Assessment of recovery coefficient (RC), noise levels, and spatial resolution.

Main Results:

  • RC values increased with sphere size and updates, ranging from 0.52-0.95 across methods.
  • Noise levels varied from 0.07 to 1.16 for OSEM and 0.07 to 0.40 for Q.Clear methods.
  • Spatial resolution (FWHM) ranged from 7.9-17.8 mm across methods.
  • Gibbs artifacts were observed in all reconstruction methods.

Conclusions:

  • Quantitative 161Tb imaging is feasible using a ring-based CZT SPECT/CT system.
  • Recommended updates: 48-96 for OSEM, ~200 for Q.Clear.
  • Optimized 161Tb imaging shows potential for improved dosimetry in RLT compared to 177Lu.