Biomimetic Nanodelivery System Based on Polyester-Lipid-Cell Membrane for the Sustained Release and Targeted...

Area of Science:

• Biomaterials Science
• Nanotechnology
• Drug Delivery

Background:

• Liposomal chemotherapy faces challenges with structural instability and premature drug leakage, leading to systemic toxicity and decreased tumor drug accumulation.
• Developing stable and targeted nanocarriers is crucial for improving the efficacy and safety of chemotherapy.

Purpose of the Study:

• To develop a robust biomimetic nanodelivery system (PDLC) that enhances lipid bilayer stability and achieves targeted drug delivery.
• To investigate the drug release characteristics, cellular uptake, and in vivo therapeutic efficacy of the PDLC system.

Main Methods:

• Synthesized a PDLC nanodelivery system with a poly(L-lactic acid) core, lipid stabilization layer, and 4T1 tumor cell membrane coating.
• Evaluated drug release profiles, pH-responsiveness, and cellular uptake via cell membrane-mediated endocytosis.
• Assessed in vivo tumor homing capabilities using imaging and determined tumor inhibition rates and cardiotoxicity.

Main Results:

• The PDLC system demonstrated suppressed initial drug release (<10% at 24 h) and pH-responsive release in acidic tumor microenvironments.
• Enhanced uptake in 4T1 cells was observed due to cell membrane-mediated endocytosis.
• In vivo studies showed superior tumor homing, an 80.1% tumor inhibition rate, and no cardiotoxicity associated with free DOX.

Conclusions:

• The developed biomimetic nanodelivery system (PDLC) effectively stabilizes liposomal chemotherapy through polymer-lipid interactions.
• PDLC offers a promising strategy for enhancing therapeutic index by improving tumor accumulation and reducing systemic toxicity.
• This biomimetic approach provides a robust platform for developing next-generation nanomedicines.