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Related Concept Videos

Esophageal Perforation-II: Clinical Manifestations and Management01:28

Esophageal Perforation-II: Clinical Manifestations and Management

Esophageal perforations manifest in various clinical forms, influenced by factors such as the perforation's cause and location (cervical, intrathoracic, or intra-abdominal), the extent of contamination, and potential injury to adjacent mediastinal structures. The timing between the perforation occurrence and treatment initiation also affects the clinical presentation.
Clinical Manifestations:
Esophageal Perforation-I: Introduction01:22

Esophageal Perforation-I: Introduction

Esophageal perforation is a severe medical condition characterized by a breach in the integrity of the esophageal wall. This breach can occur due to various factors such as trauma, medical procedures, or underlying diseases. When the esophageal wall is compromised, it allows food, fluids, and digestive juices into the chest cavity or adjacent structures, leading to potential complications and health risks.
The location of esophageal perforation can vary, occurring anywhere along the esophagus.

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Related Experiment Video

Updated: May 31, 2026

Corneal Donor Tissue Preparation for Descemet's Membrane Endothelial Keratoplasty
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Corneal Donor Tissue Preparation for Descemet's Membrane Endothelial Keratoplasty

Published on: September 17, 2014

Corneal Perforation Two Years After Mitomycin Intravascular Chemoembolization.

Trakanta Wannapanich1, Raven Diacou, Vishal Jhanji

  • 1Department of Ophthalmology (T.W.), Center of Excellence for Cornea and Stem Cell Transplantation, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Department of Ophthalmology (T.W.), Excellence Center for Cornea and Stem Cell Transplantation, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand; and Department of Ophthalmology (R.D., V.J.), UPMC Vision Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA.

Eye & Contact Lens
|May 29, 2026
PubMed
Summary
This summary is machine-generated.

A rare case of delayed corneal perforation occurred two years after Mitomycin intravascular chemoembolization (MICE) for corneal neovascularization. This highlights the need for long-term monitoring after MICE, especially in vulnerable corneas.

Keywords:
Corneal perforationMitomycinMitomycin intravascular chemoembolization

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Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
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Published on: December 2, 2022

Area of Science:

  • Ophthalmology
  • Vascular Biology
  • Regenerative Medicine

Background:

  • Corneal neovascularization (NV) poses a significant threat to vision.
  • Mitomycin intravascular chemoembolization (MICE) has emerged as a promising treatment for corneal NV.
  • Early outcomes of MICE are encouraging, but long-term complications require investigation.

Purpose of the Study:

  • To report a case of delayed corneal perforation following MICE.
  • To discuss potential mechanisms and implications of this rare complication.
  • To emphasize the importance of long-term surveillance after MICE.

Main Methods:

  • A case report of a 65-year-old male patient who underwent MICE for corneal NV.
  • Detailed clinical examination, including visual acuity and Seidel test.
  • Management of corneal perforation with corneal gluing and therapeutic patch graft.

Main Results:

  • A focal, Seidel-positive corneal perforation occurred two years post-MICE near the graft-host junction.
  • The perforation site was adjacent to previous corneal NV and lipid deposition.
  • Despite failed gluing attempts, a therapeutic patch graft led to improved visual acuity and a stable anterior chamber.

Conclusions:

  • This case suggests a potential for delayed stromal weakening after MICE in structurally compromised corneas.
  • Long-term surveillance is crucial for patients treated with MICE, particularly those with pre-existing corneal vulnerabilities.
  • Further research is needed to establish causality and elucidate the mechanisms of delayed stromal weakening post-MICE.