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Global Trends and Research Hot Spots in Medication Regimen Simplification: Bibliometric Analysis
Chuwen Dou1,2, Bei Wu2, Leyi Wu1
1Huzhou Key Laboratory of Precise Prevention and Control of Major Chronic Diseases, School of Medicine, Huzhou Normal University, No. 168 Wuxing Road, Wuxing District, Huzhou, Zhejiang, 313000, China, 86 13587278357.
JMIR Aging
|May 29, 2026
Summary
Medication regimen simplification research is growing, but collaboration is limited. Key areas include chronic diseases and adherence, with a recent focus on real-world implementation. Future studies should assess long-term impacts.
Area of Science:
- Pharmacology and Pharmacy
- Health Services Research
- Bibliometrics
Background:
- Medication regimen simplification is increasingly recognized for reducing patient burden and improving medication use.
- A systematic mapping of this field's development, knowledge structure, and themes is needed to guide research and implementation.
- Understanding research trends is crucial for optimizing medication management strategies.
Purpose of the Study:
- To analyze global research trends, collaboration patterns, and key research areas in medication regimen simplification.
- To identify emerging themes and research hot spots within the field.
- To provide insights for future research priorities and implementation strategies.
Main Methods:
- Bibliometric analysis of 468 publications from the Web of Science Core Collection (2005-2025).
- Utilized VOSviewer, CiteSpace, and Bibliometrix for analyzing publication trends, collaborations, and thematic evolution.
- Examined countries, institutions, authors, cocited references, and keyword co-occurrence.
Main Results:
- Publication output shows an upward trend, with the United States leading in publications and citations.
- Monash University is the most productive institution; collaboration is concentrated among specific country, institutional, and author clusters.
- Research has evolved from HIV-specific optimization to broader chronic disease management (e.g., type 2 diabetes, heart failure) and medication complexity.
Conclusions:
- Research in medication regimen simplification has expanded, but international collaboration requires further development.
- Current research focuses on specific diseases, adherence, and complexity, with emerging interest in real-world implementation.
- Future research should investigate the long-term effectiveness and sustainability of simplification strategies.
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