Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 31, 2026

Enhancing Tumor Content through Tumor Macrodissection
10:04

Enhancing Tumor Content through Tumor Macrodissection

Published on: February 12, 2022

Primary uveal diffuse large B-cell lymphoma: A population-based study.

Pierre Loap1, Youlia Kirova1, Rémi Dendale1

  • 1Department of Radiation Oncology, institut Curie, Paris, France.

Cancer Radiotherapie : Journal De La Societe Francaise De Radiotherapie Oncologique
|May 29, 2026
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association Between Axillary Surgical Management and Survival for Patients With De Novo Metastatic Breast Cancer.

Annals of surgical oncology·2026
Same author

European consensus on pre-operative imaging in breast cancer developed jointly by EUSOBI, ESSO, ESP and ESTRO.

European radiology·2026
Same authorSame journal

Contemporary survival outcomes of patients with isolated nodal recurrences of breast cancer: A population-based study.

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique·2026
Same authorSame journal

Radiotherapy as a curative strategy for primary pleural indolent lymphomas: Analytical guidelines based on literature and an illustrative population-based case series.

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique·2026
Same authorSame journal

Incidence and outcomes of radiation-induced sarcomas following radiotherapy for low-grade non-Hodgkin lymphomas: A population-based study.

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique·2026
Same author

Long-term outcomes and cardiac mortality after radiotherapy for primary pulmonary mucosa-associated lymphoid tissue lymphoma.

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique·2026
Same journal

White paper on radiotherapy in France: Ten objectives to strengthen one of the major modalities of cancer treatment.

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique·2026
Same journal

Factors affecting the stability of deep inspiration breath-holding in radiotherapy for left-sided breast cancers.

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique·2026
Same journal

Cone-beam computed tomography-based radiomics for tumour regression assessment during radiotherapy of non-small-cell lung cancer.

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique·2026
See all related articles

Primary uveal diffuse large B-cell lymphoma is a rare, aggressive cancer. While outcomes are poor, some localized cases may achieve long-term remission, suggesting radiotherapy as a potential treatment.

Area of Science:

  • Ophthalmology
  • Oncology
  • Hematology

Background:

  • Primary uveal tract involvement by diffuse large B-cell lymphoma (DLBCL) is rare.
  • Ocular lymphomas are often indolent mucosa-associated lymphoid tissue (MALT) lymphomas with good prognoses.
  • Limited data exists on the characteristics of primary uveal DLBCL.

Purpose of the Study:

  • To evaluate the epidemiologic and clinical features of primary uveal diffuse large B-cell lymphoma.
  • To analyze survival outcomes in patients with this rare malignancy.
  • To compare primary uveal DLBCL with other ocular lymphomas.

Main Methods:

  • Retrospective analysis of the Surveillance, Epidemiology, and End Results (SEER) database (2000-2022).
  • Inclusion criteria: histologically confirmed DLBCL with primary localization in the choroid or ciliary body/iris.
Keywords:
CancerEpidemiologyEye cancerLymphomaLymphomeÉpidémiologieŒil

More Related Videos

Cell-Free DNA Extraction of Vitreous and Aqueous Humor Specimens for Diagnosis and Monitoring of Vitreoretinal Lymphoma
06:20

Cell-Free DNA Extraction of Vitreous and Aqueous Humor Specimens for Diagnosis and Monitoring of Vitreoretinal Lymphoma

Published on: January 12, 2024

Related Experiment Videos

Last Updated: May 31, 2026

Enhancing Tumor Content through Tumor Macrodissection
10:04

Enhancing Tumor Content through Tumor Macrodissection

Published on: February 12, 2022

Cell-Free DNA Extraction of Vitreous and Aqueous Humor Specimens for Diagnosis and Monitoring of Vitreoretinal Lymphoma
06:20

Cell-Free DNA Extraction of Vitreous and Aqueous Humor Specimens for Diagnosis and Monitoring of Vitreoretinal Lymphoma

Published on: January 12, 2024

  • Survival analysis using Kaplan-Meier estimates and Cox univariate models.

    • Main Results:

    • 51 cases (0.038%) of primary uveal DLBCL identified among 134,366 DLBCL cases.
    • Median age 65 years; predominantly Caucasian patients.
    • 5-year overall survival: 45.5%; 5-year cancer-specific survival: 58.4%.
    • Localized disease showed a 5-year cancer-specific survival of 59.4% with a plateau after 6 years.
    • No significant survival associations with clinical or treatment variables (radiotherapy, chemotherapy).

    Conclusions:

    • Primary uveal DLBCL is an ultra-rare, aggressive malignancy distinct from uveal MALT lymphoma.
    • Outcomes are generally poorer than MALT lymphoma, but localized disease may lead to long-term remission.
    • Radiotherapy might be a treatment option for selected patients; optimal management requires further investigation.
    • Further prospective studies are needed to define optimal management strategies.