Related Experiment Video
Updated: May 31, 2026
Application of an Amplitude-integrated EEG Monitor (Cerebral Function Monitor) to Neonates
Published on: September 6, 2017
An objective and simple aEEG parameter for predicting neurological outcomes in extremely preterm infants
C Cortes-Ledesma1, N Oikonomopoulou1, L Arruza1
1Hospital Clínico San Carlos, Neonatology Department, Instituto de Investigación Sanitaria Hospital Clínico San Carlos (IdISSC), Madrid, Spain.
Aim:
To evaluate the utility of the amplitude-integrated EEG (aEEG) continuity index (CI) in predicting neurodevelopmental outcomes in extremely low gestational-age newborns (ELGANs).
Methods:
Between January 2020 and December 2022 80 newborns <28 weeks of gestational age were eligible for the study. The aEEG was analyzed using the Burdjalov score (BS) and the CI from day 1 to week 4 of life. Interrater reliability was calculated. Patients were classified as having an adverse short-term outcome if they died or survived with significant neuroimaging abnormalities. Otherwise, they were classified as having a favorable outcome. Long-term outcomes were evaluated using the Bayley Scales Third Edition at 24-months-corrected-age.
Results:
Both CI and BS were strong predictors of adverse outcomes in the short- and long-term, with the greatest differences between children with adverse and favorable outcomes observed on day 4 of life. However, CI demonstrated superior interrater reliability compared to BS (intraclass correlation coefficient: 0.979 vs. 0.68). The lack of increase in CI from days 1-4 also proved to be a good predictor. Analysis of potential confounding factors revealed that CI was independent of sedation and pre-existing intraventricular hemorrhages.
Conclusion:
CI could be a valuable quantitative and easy-to-calculate screening tool for identifying ELGANs at risk for adverse outcomes.
