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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
Overview of Systemic Arteries01:11

Overview of Systemic Arteries

The human body is a complex, well-organized machine, and at the heart of its operations lies the circulatory system. This network of blood vessels, which includes systemic arteries, plays a vital role in maintaining life by transporting nutrients, oxygen, and waste products to and from cells throughout the body.
Systemic circulation is the part of the cardiovascular system that carries oxygenated blood away from the heart to the body's tissues and returns deoxygenated blood back to the heart.
Myasthenia Gravis ll: Pathophysiology01:22

Myasthenia Gravis ll: Pathophysiology

The disease process of myasthenia gravis begins at the neuromuscular junction, where antibodies attack key proteins needed for muscle activation. This immune reaction weakens signal transmission, leading to the characteristic muscle fatigue and weakness that define the condition.Immune-Mediated DamageIn most individuals, antibodies target acetylcholine receptors (AChRs) on the postsynaptic membrane of muscle cells. By blocking acetylcholine binding, these antibodies prevent the nerve signal...
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...

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Related Experiment Video

Updated: May 31, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

[Focus on systemic sclerosis].

Jörg Henes1, Ann-Christin Pecher1

  • 1University of Tubingen, Rheumatologie, Baden-Württemberg, Germany, Tubingen.

Deutsche Medizinische Wochenschrift (1946)
|May 29, 2026
PubMed
Summary
This summary is machine-generated.

New European and German guidelines offer updated strategies for diagnosing and treating systemic sclerosis. This overview highlights key recommendations, focusing on early identification and B-cell therapies for improved patient outcomes.

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Last Updated: May 31, 2026

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Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice

Published on: March 24, 2017

Area of Science:

  • Rheumatology and Immunology
  • Autoimmune Diseases
  • Connective Tissue Disorders

Background:

  • Systemic sclerosis is a complex autoimmune connective tissue disease.
  • Recent 2024 European Alliance of Associations for Rheumatology (EULAR) treatment recommendations have been updated.
  • German recommendations now amend these guidelines for diagnosis and therapy.

Purpose of the Study:

  • To provide physicians with an overview of the new diagnostic and therapeutic recommendations.
  • To aid in the earlier identification of patients with characteristic systemic sclerosis features.
  • To improve early diagnosis and enhance future treatment strategies, particularly B-cell targeting therapies.

Main Methods:

  • Review and synthesis of the 2024 EULAR recommendations.
  • Inclusion and analysis of the amended German recommendations for systemic sclerosis.
  • Focus on clinical features relevant for early diagnosis.
  • Examination of B-cell targeting therapies within the new guidelines.

Main Results:

  • The article outlines updated diagnostic criteria and therapeutic approaches for systemic sclerosis.
  • Emphasis is placed on recognizing typical clinical signs for prompt patient identification.
  • The recommendations provide a framework for optimizing early management strategies.

Conclusions:

  • Adherence to the updated EULAR and German recommendations can facilitate earlier systemic sclerosis diagnosis.
  • Early identification enables timely initiation of appropriate treatments.
  • The guidelines underscore the importance of considering B-cell targeting therapies in managing systemic sclerosis.