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Published on: November 14, 2017
Impact of ABCB1 (rs1045642) polymorphism on antipsychotic-induced extrapyramidal symptoms in Egyptian patients with
Asmaa Mohamed Sayed Ahmed1, Asmaa Mohammad Moawad1, Mennat-Allah Tarek2
1Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Cairo University, Kasr Alainy Street, Cairo, 11562, Egypt.
Abstract:
The ABCB1 polymorphisms may influence risperidone-induced extrapyramidal symptoms (EPS) in schizophrenia. This cross-sectional study examined the relationships among ABCB1 variants, clinical factors, and objective, subjective EPS in 150 patients receiving risperidone at Kasr al-Ainy Hospital, Cairo University, who were genotyped for ABCB1 (rs1045642) and assessed via BARS, SAS, and LUNSERS. The genotype frequencies were CC (44.7%), CT (40.7%), and TT (14.7%). EPS occurred more frequently in TT (59.1%) and CT (52.5%) carriers than in CC carriers (29.9%). Results revealed increased EPS risk for TT (OR = 3.39, P = 0.016) and CT (OR = 2.59, P = 0.010). In multivariate analysis, TT (OR = 15.77, 95% CI: 3.11-79.89, P = 0.001) and CT (OR = 5.51, 95% CI: 1.77-17.16, P = 0.003) remained independent predictors, whereas longer illness duration increased risk (OR = 1.089, 95% CI: 1.022-1.161, P = 0.008) and smoking was protective (OR = 0.31, 95% CI: 0.12-0.80, P = 0.015). The ABCB1 genotype significantly impacted subjective (LUNSERS; p = 0.012) and objective (SAS; p = 0.009), whereas objective (BARS) showed no significant association (p = 0.281). The ABCB1 TT and CT genotypes increase susceptibility to risperidone-induced EPS. These findings support using pharmacogenomic screening to guide personalized therapy and reduce EPS risk.
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