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Published on: August 24, 2019
Performance of multiple case-finding approaches in detecting chronic obstructive pulmonary disease: a systematic
Dongru Du1, Sike He2, Shujin Guo3
1Department of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China; State Key Laboratory of Respiratory Health and Multimorbidity, West China Hospital, Sichuan University, Chengdu, China.
The COPD diagnostic questionnaire (CDQ) shows the highest sensitivity for screening chronic obstructive pulmonary disease (COPD). However, other methods like COLA-6 offer better specificity for COPD case-finding.
Area of Science:
- Pulmonary Medicine
- Diagnostic Accuracy
- Epidemiology
Background:
- Chronic obstructive pulmonary disease (COPD) poses a significant global health burden.
- Effective screening strategies are crucial for early detection and management of COPD.
- Various case-finding approaches exist, but their comparative diagnostic performance requires thorough evaluation.
Purpose of the Study:
- To systematically review and compare the diagnostic performance of different screening methods for COPD.
- To identify the most sensitive and specific approaches for COPD case-finding.
Main Methods:
- A systematic review and network meta-analysis of studies evaluating COPD screening tools.
- Inclusion of studies from major databases (PubMed, Embase, Web of Science, Scopus).
- Direct meta-analysis for pooled sensitivity, specificity, and AUC, followed by network meta-analysis and SUCRA for ranking.
Main Results:
- The COPD diagnostic questionnaire (CDQ) demonstrated the highest sensitivity (0.78) and AUC (0.76).
- In network meta-analysis, CDQ, CAPTURE, and IPAG ranked highest for sensitivity.
- COLA-6, COPD-SQ combined with PEF, and PUMA showed the highest specificity.
Conclusions:
- The CDQ is a highly sensitive tool for COPD screening.
- COLA-6 and COPD-SQ with PEF are more specific for identifying COPD cases.
- Further research is needed to optimize COPD screening strategies across diverse settings.
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