Related Experiment Video
Updated: May 31, 2026
08:35
In Situ Immunofluorescent Staining of Autophagy in Muscle Stem Cells
Published on: June 12, 2017
CREB-SEC61G feedback loop sustains enhanced autophagy and boosts proliferation in PDAC
Xiao Wu1, Xinyan Wu2, Yihang Nan1
1Department of General Surgery, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
Cell Death & Disease
|May 29, 2026
Summary
SEC61G promotes pancreatic ductal adenocarcinoma (PDAC) growth by enhancing autophagy through a calcium-dependent positive feedback loop involving CREB. This highlights SEC61G as a potential prognostic biomarker and therapeutic target for PDAC.
Area of Science:
- Oncology
- Molecular Biology
- Cell Biology
Background:
- Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer with increasing incidence.
- Autophagy is crucial for PDAC tumor survival.
- The role of SEC61G in PDAC progression is not well understood.
Purpose of the Study:
- To investigate the mechanism by which SEC61G influences PDAC progression.
- To determine if SEC61G can serve as a prognostic biomarker for PDAC.
- To explore SEC61G as a potential therapeutic target for PDAC.
Main Methods:
- Analysis of SEC61G expression in PDAC tissues and correlation with patient prognosis.
- In vitro and in vivo experiments to assess SEC61G's effect on PDAC cell proliferation.
- Investigation of SEC61G's role in regulating autophagy and intracellular calcium levels.
- Exploration of the SEC61G-CREB signaling pathway.
Main Results:
- SEC61G is overexpressed in PDAC and associated with poor patient prognosis.
- SEC61G promotes PDAC cell proliferation both in vitro and in vivo.
- SEC61G enhances autophagy in a calcium leakage-dependent manner.
- SEC61G activates CREB, forming a positive feedback loop that enhances SEC61G expression and sustains autophagy.
Conclusions:
- SEC61G overexpression drives PDAC progression by enhancing autophagy via a calcium-dependent positive feedback loop with CREB.
- SEC61G represents a promising prognostic biomarker for PDAC.
- SEC61G is a potential therapeutic target for PDAC treatment.
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