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Updated: May 31, 2026

Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding
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Structural characterization of kappa-opioid receptor dimer in complex with two G proteins

Yuxi Zhao1,2, Chanjuan Xu3, Yue Wang1

  • 1State Key Laboratory of Drug Research. Center for Structure and Function of Drug Targets, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.

Nature Communications
|May 29, 2026
PubMed
Summary

The κ-opioid receptor (κOR) forms stable dimers, enhancing its signaling for pain relief. This discovery provides a basis for developing new non-addictive pain therapeutics targeting κOR.

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