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Updated: May 31, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
11:51

Facile Preparation of 4-Substituted Quinazoline Derivatives

Published on: February 15, 2016

Mechanochemical Single-Carbon Insertion into (Iso)quinolines

Chunxiu Jing1, Fanchen Huang1, Xiaotong Liang1

  • 1Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi'an, 710069, China.

Nature Communications
|May 29, 2026
PubMed
Summary

Researchers developed a new mechanochemical method to convert (iso)quinolines into benzoazepines. This efficient skeletal editing technique offers a valuable route to diverse benzoazepine drug candidates under mild conditions.

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