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Updated: May 31, 2026

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

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Published on: October 15, 2019

Early-life Gut Microbiota and Allergic Diseases: Immune Regulatory Mechanisms and Intervention Progress

Lei Yu1,2, Maolan Wu1,2, Tingfan Leung3

  • 1Department of Pediatrics, Xiangya Hospital, Central South University, Changsha, Hunan, China.

Clinical Reviews in Allergy & Immunology
|May 29, 2026
PubMed

Insights

The gut microbiota, or gut bacteria, significantly impacts children's allergies. Early life gut health is key to preventing and treating allergic diseases like asthma and eczema.

Area of Science:

  • Immunology
  • Microbiology
  • Public Health

Background:

  • Allergic diseases are rising globally, especially in children.
  • Gut microbiota dysbiosis is increasingly linked to allergic disease development.
  • The gut microbiome influences immune development and tolerance in early life.

Purpose of the Study:

  • To review the relationship between early-life gut microbiota and allergic diseases.
  • To summarize the immunoregulatory mechanisms involved.
  • To discuss microbiota-targeted interventions for prevention and treatment.

Main Methods:

  • Literature review of studies on gut microbiota and allergies.
  • Analysis of immunoregulatory pathways.
  • Evaluation of current and emerging microbiota-based interventions.

Main Results:

  • Gut microbiota composition and function are critical for immune homeostasis.
  • Dysbiosis can promote susceptibility to atopic dermatitis, asthma, and allergic rhinitis.
  • Early-life microbial exposures shape long-term allergic outcomes.

Conclusions:

  • Early-life gut microbiota plays a crucial role in allergic disease development.
  • Understanding these mechanisms can guide targeted interventions.
  • Microbiota-focused strategies offer potential for allergy prevention and precision treatment.

Keywords:
Allergic diseasesEarly lifeGut microbiotaImmune regulationMicroecological intervention

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