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Low expression of miR-126 constitutes a risk factor for perioperative respiratory adverse events among pediatric

Wenjuan Luo1, Kaili Lv2, Jun Liu3

  • 1Department of General Surgery, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, 310052, China.

BMC Pediatrics
|May 29, 2026
PubMed

Insights

MicroRNA-126 (miR-126) is downregulated in children experiencing perioperative respiratory adverse events (PRAEs). Low miR-126 levels are a risk factor, suggesting its potential as a diagnostic biomarker for PRAEs.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Pediatric Medicine

Background:

  • Perioperative respiratory adverse events (PRAEs) are common in pediatric surgery.
  • Identifying reliable biomarkers for PRAEs is crucial for early diagnosis and management.

Purpose of the Study:

  • To investigate the diagnostic value of microRNA-126 (miR-126) in pediatric patients experiencing PRAEs.
  • To explore the correlation between miR-126 levels and inflammatory markers.

Main Methods:

  • Serum miR-126 levels were quantified using RT-qPCR in 228 pediatric patients.
  • Cell proliferation was assessed via CCK-8 assay.
  • Inflammatory cytokines (TNF-α, IL-6, IL-13) were measured using ELISA.
  • Diagnostic accuracy was evaluated using receiver operating characteristic (ROC) curve analysis.

Main Results:

  • miR-126 was significantly downregulated in children with PRAEs compared to controls.
  • Lower miR-126 expression was identified as a risk factor for PRAEs.
  • miR-126 levels negatively correlated with serum inflammatory markers.
  • Overexpression of miR-126 enhanced cell proliferation in vitro.

Conclusions:

  • miR-126 may serve as a valuable diagnostic biomarker for PRAEs in pediatric patients.
  • miR-126 may play a role in suppressing PRAEs by modulating proliferation and inflammatory responses.
Abstract

Keywords:
Cell proliferationInflammationPerioperative respiratory adverse eventsmiR-126

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