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Association between hepatitis C virus and overactive bladder: a cross-sectional study based on the 2013-2018 NHANES
Yiming Ding1,2, Tonglei Zhao2, Jie Ji2
1Department of Urology, Nanjing Lishui District People's Hospital, Zhongda Hospital Lishui Branch, Southeast University, Nanjing, 211200, China.
BMC Urology
|May 29, 2026
Summary
Hepatitis C virus (HCV) infection is linked to overactive bladder (OAB) in adults. This study found a significant correlation, suggesting HCV may be a risk factor for OAB development.
Area of Science:
- Urology
- Infectious Diseases
- Public Health
Background:
- Overactive bladder (OAB) is a prevalent urological condition impacting quality of life.
- Hepatitis C virus (HCV) infection is associated with systemic inflammation and extrahepatic complications.
- The potential association between HCV and OAB remains understudied.
Purpose of the Study:
- To investigate the association between Hepatitis C virus (HCV) and overactive bladder (OAB) in adults.
- To determine if HCV is a risk factor for OAB.
Main Methods:
- Analysis of National Health and Nutrition Examination Survey (NHANES) data (2013-2018).
- Logistic regression, subgroup analyses, and interaction tests were used.
- Propensity score matching (PSM), inverse probability weighting (IPTW), and overlap weighting (OW) controlled for confounders.
Main Results:
- A significant association was found between HCV and OAB (OR = 2.06, p < 0.001).
- The association remained consistent across subgroups and robust after controlling for confounders.
- HCV demonstrated predictive value for OAB.
Conclusions:
- This study establishes a significant correlation between HCV infection and OAB.
- HCV may be an independent risk factor for the development of OAB.
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