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Published on: June 14, 2020

Iron status, hepcidin, and CRP in children with endoscopically confirmed adenotonsillar hypertrophy: a controlled

Serhan Keskin1, Nurşen Keskin2

  • 1Department of Otolaryngology, Head and Neck Surgery, Gebze Fatih State Hospital, Gebze, Kocaeli, Turkey. serhankeskin@live.com.

BMC Pediatrics
|May 29, 2026
PubMed

Insights

Adenotonsillar hypertrophy (ATH) in children does not significantly impact iron levels or inflammation markers. Routine iron evaluation is not recommended solely based on ATH, but targeted assessment may be useful for specific clinical signs.

Area of Science:

  • Pediatric Health
  • Hematology
  • Immunology

Background:

  • Adenotonsillar hypertrophy (ATH) may affect iron homeostasis and inflammation in children.
  • Previous findings on ATH's impact on iron status and inflammation in children are inconsistent.

Purpose of the Study:

  • To compare hematologic, iron-related, and inflammatory parameters in children with and without endoscopically confirmed ATH.
  • To investigate the association between ATH and iron deficiency, anemia, and inflammation markers.

Main Methods:

  • Controlled cross-sectional study of 300 children (6-12 years old): 150 with ATH, 150 controls.
  • Measured hemoglobin, serum iron, ferritin, mean corpuscular volume (MCV), C-reactive protein (CRP), and hepcidin.
  • Defined iron deficiency and anemia using World Health Organization criteria.

Main Results:

  • No statistically significant differences in hemoglobin, iron indices, CRP, or hepcidin between children with and without ATH.
  • Iron deficiency prevalence: 30% in ATH group vs. 24% in controls (p=0.24).
  • Iron-deficiency anemia prevalence: 10% in ATH group vs. 8% in controls (p=0.55).

Conclusions:

  • ATH is not associated with significant differences in routine iron indices, CRP, or hepcidin in this cohort.
  • Findings do not support routine iron evaluation solely based on ATH.
  • Targeted iron assessment may be considered for children with relevant clinical findings related to ATH.
Abstract

Keywords:
Adenotonsillar hypertrophyC-reactive proteinChildrenHepcidinIron status

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