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Related Experiment Video

Updated: May 31, 2026

Digital Handwriting Analysis of Characters in Chinese Patients with Mild Cognitive Impairment
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Published on: March 11, 2021

Multidimensional cognitive deficit in logopenic variant primary progressive aphasia: a case report.

Vivien Puspitasari1,2, Yetty Ramli1, Diatri Nari Lastri1

  • 1Department of Neurology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.

Journal of Medical Case Reports
|May 29, 2026
PubMed
Summary

Logopenic variant primary progressive aphasia (lvPPA), a language disorder in Alzheimer's disease, can be missed in older adults with other health issues. Early language assessment is crucial for diagnosis, especially in diverse clinical settings.

Keywords:
Alzheimer’s diseaseLogopenic variant primary progressive aphasia

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Published on: June 25, 2019

Area of Science:

  • Neurology
  • Geriatrics
  • Linguistics

Background:

  • Logopenic variant primary progressive aphasia (lvPPA) presents as a language disorder, often associated with Alzheimer's disease.
  • It is frequently misdiagnosed in elderly patients with co-existing vascular and systemic conditions.

Purpose of the Study:

  • To present a case study of lvPPA in an elderly patient with multiple comorbidities.
  • To emphasize the diagnostic challenges and importance of tailored assessments in mixed dementia.

Main Methods:

  • A case report of a 78-year-old woman with progressive word-finding difficulties and cognitive decline.
  • Utilized serial Indonesian neuropsychological tests (MMSE, MoCA-Ina, CERAD, TADIR) and MRI.
  • Assessed the impact of pharmacological and rehabilitative interventions.

Main Results:

  • The patient exhibited initial amnestic and executive deficits, progressing to severe anomia and impaired repetition.
  • MRI revealed mixed Alzheimer and vascular pathology (temporo-parietal atrophy, white matter disease).
  • Partial symptomatic improvement was observed with donepezil, clobazam, and rehabilitation.

Conclusions:

  • Accurate diagnosis of lvPPA requires thorough language evaluation, even with comorbidities.
  • Culturally adapted neuropsychological tools are vital for identifying lvPPA in mixed dementia, particularly in resource-limited environments.