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Multidimensional cognitive deficit in logopenic variant primary progressive aphasia: a case report.
Vivien Puspitasari1,2, Yetty Ramli1, Diatri Nari Lastri1
1Department of Neurology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Journal of Medical Case Reports
|May 29, 2026
Summary
Logopenic variant primary progressive aphasia (lvPPA), a language disorder in Alzheimer's disease, can be missed in older adults with other health issues. Early language assessment is crucial for diagnosis, especially in diverse clinical settings.
Area of Science:
- Neurology
- Geriatrics
- Linguistics
Background:
- Logopenic variant primary progressive aphasia (lvPPA) presents as a language disorder, often associated with Alzheimer's disease.
- It is frequently misdiagnosed in elderly patients with co-existing vascular and systemic conditions.
Purpose of the Study:
- To present a case study of lvPPA in an elderly patient with multiple comorbidities.
- To emphasize the diagnostic challenges and importance of tailored assessments in mixed dementia.
Main Methods:
- A case report of a 78-year-old woman with progressive word-finding difficulties and cognitive decline.
- Utilized serial Indonesian neuropsychological tests (MMSE, MoCA-Ina, CERAD, TADIR) and MRI.
- Assessed the impact of pharmacological and rehabilitative interventions.
Main Results:
- The patient exhibited initial amnestic and executive deficits, progressing to severe anomia and impaired repetition.
- MRI revealed mixed Alzheimer and vascular pathology (temporo-parietal atrophy, white matter disease).
- Partial symptomatic improvement was observed with donepezil, clobazam, and rehabilitation.
Conclusions:
- Accurate diagnosis of lvPPA requires thorough language evaluation, even with comorbidities.
- Culturally adapted neuropsychological tools are vital for identifying lvPPA in mixed dementia, particularly in resource-limited environments.
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