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Updated: May 31, 2026
07:10
Measurement of the Hepatic Venous Pressure Gradient and Transjugular Liver Biopsy
Published on: June 18, 2020
Risk factors for rebleeding at different time points after TIPS in cirrhotic patients with AEVB: A case-control study
Chunxiu Tan1, Wentun Yao2, Houqiang Su2
1The First Clinical Medical College, Ningxia Medical University, Yinchuan, China.
Medicine
|May 30, 2026
Summary
Higher preoperative fasting blood glucose (FBG) may reduce early rebleeding after transjugular intrahepatic portosystemic shunt (TIPS). Male gender and infection increase late rebleeding risk in cirrhotic patients with acute esophagogastric variceal bleeding (AEVB).
Area of Science:
- Hepatology
- Interventional Radiology
- Gastroenterology
Background:
- Transjugular intrahepatic portosystemic shunt (TIPS) is used for acute esophagogastric variceal bleeding (AEVB) in cirrhotic patients.
- Rebleeding after TIPS can occur early or late, necessitating identification of risk factors.
- Predicting rebleeding is crucial for patient management and outcomes.
Purpose of the Study:
- To identify independent risk factors for early (≤6 weeks) and late (>2 years) rebleeding post-TIPS in cirrhotic patients with AEVB.
- To stratify patient risk for rebleeding based on preoperative factors.
- To inform perioperative management strategies for TIPS procedures.
Main Methods:
- Retrospective case-control study of 208 consecutive patients undergoing TIPS for AEVB.
- Follow-up until May 2025 to assess rebleeding events.
- Multivariate logistic regression analysis to determine independent predictors of early and late rebleeding.
Main Results:
- Elevated preoperative fasting blood glucose (FBG) was a protective factor against early rebleeding (OR=0.861, P=.013).
- Male gender (OR=3.820, P=.039) and preoperative infection (OR=6.490, P=.001) were independent risk factors for late rebleeding.
- 5.8% experienced early rebleeding; 10.1% experienced late rebleeding.
Conclusions:
- Preoperative FBG levels may influence early rebleeding risk after TIPS.
- Male sex and preoperative infection are significant predictors of late rebleeding post-TIPS.
- Findings aid in risk stratification and optimizing perioperative care for AEVB patients undergoing TIPS.
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