Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Bone Marrow Sampling and Transplants

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Biallelic inactivating variants in the chromatin remodeler DMAP1 cause a syndromic neurodevelopmental disorder.

The Journal of clinical investigation·2026

Same author

Universal Presence of Gene/Variant Nomenclature Errors in Journal Manuscript Submissions.

Clinical chemistry·2026

Same author

Effect of Dietary Sodium Nitrite Supplementation on Spontaneous Intracerebral Hemorrhage in Stroke-Prone Spontaneously Hypertensive Rats.

Preventive nutrition and food science·2026

Same author

Rituximab as acute rescue therapy for paediatric MOGAD refractory to standard treatment.

BMJ case reports·2026

Same author

Predicting subtypes of glycogen storage disease type IV: Challenges of hepatic subtypes and genotype-phenotype correlation.

Molecular genetics and metabolism·2025

Same author

Acute myocardial infarction in an adolescent following recurrent Kikuchi-Fujimoto disease.

BMJ case reports·2025

Search research articles

Related Experiment Video

Updated: May 31, 2026

Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies

Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies

Published on: September 6, 2017

Pure Red Cell Aplasia Associated With Recipient B-Cell Mixed Chimerism Successfully Treated With Rituximab.

Norifumi Yokoyama¹, Taichi Miyazaki¹, Tomoaki Hirate¹

¹Department of Pediatrics・Pediatric Hematology/Oncology, Gifu Municipal Hospital, Gifu, Japan.

Pediatric Transplantation

|May 30, 2026

Summary

This summary is machine-generated.

Pure red cell aplasia (PRCA) after hematopoietic stem cell transplantation (HSCT) may stem from persistent recipient B cells. Targeted therapy with rituximab successfully treated PRCA and restored donor B-cell chimerism.

Area of Science:

Hematology
Immunology
Transplantation

Background:

Pure red cell aplasia (PRCA) is a rare complication of allogeneic hematopoietic stem cell transplantation (HSCT).

Keywords:

hematopoietic stem cell transplantation mixed chimerism pure red cell aplasia rituximab

More Related Videos

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis

Published on: May 26, 2021

In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells

In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells

Published on: February 16, 2024

Related Experiment Videos

Last Updated: May 31, 2026

Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies

Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies

Published on: September 6, 2017

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis

Published on: May 26, 2021

In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells

In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells

Published on: February 16, 2024

Major ABO incompatibility increases PRCA risk post-HSCT.

Standard chimerism assays may miss lineage-specific immune issues causing complications.