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Related Concept Videos

EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
Chromatin Modification in iPS Cells01:32

Chromatin Modification in iPS Cells

Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
Compact chromatin makes reprogramming difficult. Enzymes, such as histone demethylases and acetyltransferases, are often added during reprogramming to loosen the chromatin, making the DNA more accessible to transcription factors. Molecules that inhibit histone...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.

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Related Experiment Video

Updated: May 31, 2026

Absolute Quantitation of Inositol Pyrophosphates by Capillary Electrophoresis Electrospray Ionization Mass Spectrometry
09:22

Absolute Quantitation of Inositol Pyrophosphates by Capillary Electrophoresis Electrospray Ionization Mass Spectrometry

Published on: August 13, 2021

Inositol Hexaphosphate as a Metabolic Rheostat: Reprogramming and Plasticity in Stem Cells and Disease States.

Jr-Yu Lin1,2,3, Cheryl C H Yang3,4,5, Yi-Chao Hsu1,2

  • 1Department of Audiology and Speech-Language Pathology, Mackay Medical University, 252005 New Taipei City, Taiwan.

Frontiers in Bioscience (Landmark Edition)
|May 30, 2026
PubMed
Summary

Inositol hexaphosphate (IP6) regulates cellular metabolism, preserving stem cell function and counteracting disease-related metabolic changes. This metabolic rheostat shows promise for regenerative medicine and disease treatment.

Keywords:
apoptosisbiomedicalglycolysismetabolic reprogrammingphytic acidstem celltranslational science

More Related Videos

Extraction and Quantification of Soluble, Radiolabeled Inositol Polyphosphates from Different Plant Species using SAX-HPLC
09:01

Extraction and Quantification of Soluble, Radiolabeled Inositol Polyphosphates from Different Plant Species using SAX-HPLC

Published on: June 26, 2020

Identification of Inositol Phosphate or Phosphoinositide Interacting Proteins by Affinity Chromatography Coupled to Western Blot or Mass Spectrometry
08:07

Identification of Inositol Phosphate or Phosphoinositide Interacting Proteins by Affinity Chromatography Coupled to Western Blot or Mass Spectrometry

Published on: July 26, 2019

Related Experiment Videos

Last Updated: May 31, 2026

Absolute Quantitation of Inositol Pyrophosphates by Capillary Electrophoresis Electrospray Ionization Mass Spectrometry
09:22

Absolute Quantitation of Inositol Pyrophosphates by Capillary Electrophoresis Electrospray Ionization Mass Spectrometry

Published on: August 13, 2021

Extraction and Quantification of Soluble, Radiolabeled Inositol Polyphosphates from Different Plant Species using SAX-HPLC
09:01

Extraction and Quantification of Soluble, Radiolabeled Inositol Polyphosphates from Different Plant Species using SAX-HPLC

Published on: June 26, 2020

Identification of Inositol Phosphate or Phosphoinositide Interacting Proteins by Affinity Chromatography Coupled to Western Blot or Mass Spectrometry
08:07

Identification of Inositol Phosphate or Phosphoinositide Interacting Proteins by Affinity Chromatography Coupled to Western Blot or Mass Spectrometry

Published on: July 26, 2019

Area of Science:

  • Biochemistry and Molecular Biology
  • Cellular Metabolism
  • Stem Cell Biology

Background:

  • Inositol hexaphosphate (IP6) is a natural carbohydrate found in grains, legumes, and cells.
  • IP6 is recognized as a key regulator of cellular metabolism and plasticity.
  • Its role in stem cells and disease states is an area of growing interest.

Purpose of the Study:

  • To review how IP6 modulates metabolic reprogramming and plasticity in stem cells and disease states.
  • To discuss the translational medicine implications of these IP6 mechanisms.
  • To explore IP6's influence on central metabolic circuits and epigenetic landscapes.

Main Methods:

  • Literature review of IP6's role in cellular metabolism.
  • Analysis of IP6's impact on stem cell self-renewal and differentiation.
  • Examination of IP6's effects in pathological conditions like cancer.
  • Investigation of IP6's influence on epigenetic modifications.

Main Results:

  • IP6 modulates glycolysis, oxidative phosphorylation, and redox balance.
  • In stem cells, IP6 enhances energy utilization, antioxidant defenses, and pluripotency.
  • In cancer, IP6 attenuates aerobic glycolysis, modulates PI3K/Akt/mTOR signaling, and restores mitochondrial integrity, inducing growth arrest and apoptosis.
  • IP6 influences epigenetic landscapes via metabolite-dependent chromatin remodeling.

Conclusions:

  • IP6 acts as a versatile metabolic rheostat, preserving stem cell function and combating maladaptive metabolic reprogramming in diseases.
  • IP6's pleiotropic effects are relevant to neurodegeneration, hearing loss, and metabolic syndromes.
  • Further research is needed to define IP6-regulated checkpoints and targets for therapeutic applications.