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Updated: May 31, 2026
08:09
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Published on: July 25, 2017
Tubulo-Squamous Vaginal Polyp: A Clinicopathologic Series with Literature Review
Bushra K Al-Tarawneh1,2, Sadeq Islam1, M Ruhul Quddus1
1Pathology and Laboratory Medicine, Women and Infants Hospital of Rhode Island, Warren Alpert Medical School of Brown University, Providence, RI, USA.
International Journal of Surgical Pathology
|May 30, 2026
Summary
Tubulo-squamous polyps (TSPs) are rare vaginal lesions in postmenopausal women. Their histological features suggest a link to Mullerian epithelial changes possibly influenced by testosterone.
Area of Science:
- Gynecologic pathology
- Vaginal pathology
- Endocrinology
Background:
- Tubulo-squamous polyp (TSP) is a rare, benign vaginal lesion.
- Typically observed in postmenopausal women.
- Origin and pathogenesis remain unclear, with hypotheses involving misplaced prostate-like vaginal skene glands.
Purpose of the Study:
- To describe the clinical, histological, and immunohistochemical features of 6 TSPs.
- To investigate the potential origin and nature of TSPs.
Main Methods:
- Case series of 6 TSPs encountered in routine practice.
- Histological examination.
- Immunohistochemical analysis.
Main Results:
- TSPs present as mass-forming, submucosal lesions.
- Histology shows cystic metaplastic transitional-type epithelium and prostate-like glands.
- Immunohistochemical findings are consistent with Mullerian epithelial metaplasia.
Conclusions:
- The histological and immunohistochemical profile of TSPs mirrors Mullerian metaplastic changes.
- These changes may be associated with exogenous testosterone exposure.
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