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NIR-II-Trackable LYTACs Phyto-Nanotheranostics for Source-Microenvironment Dual-Track ROS Regulation in Acute Gouty

Jian Zhang1, Yingying Wang1, Lujie Yu1

  • 1Laboratory of Molecular Imaging, Fifth Hospital of Shanxi Medical University (Shanxi Provincial People's Hospital), Taiyuan, China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|May 30, 2026
PubMed
Summary

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This summary is machine-generated.

A novel nanomaterial, TPR-LYTACs, precisely targets and regulates reactive oxygen species (ROS) to treat acute gouty arthritis (GA). This approach inhibits ROS at the source and scavenges them, offering a new therapeutic strategy for inflammatory diseases.

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Immunology

Background:

  • Gouty arthritis (GA) pathogenesis involves NOX2-mediated reactive oxygen species (ROS) in macrophages.
  • Current treatments for GA lack precise control over ROS production.

Purpose of the Study:

  • To develop a novel nanomaterial, TPR-LYTACs, for precise ROS regulation in acute GA.
  • To establish a new therapeutic strategy for inflammatory diseases based on dual-pathway ROS control.

Main Methods:

  • Constructed TPR-LYTACs using a nano-core (TPR) of tea polyphenols and acidified rutin.
  • Conjugated the TPR core with a NOX2-targeting antibody and maleylated bovine serum albumin for dual-pathway ROS regulation.
  • Evaluated TPR-LYTACs in an acute GA rat model using near-infrared-II fluorescence imaging.
Keywords:
Acute gouty arthritisNADPH oxidase 2TPR‐LYTACsimmunotherapymacrophage

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Main Results:

  • TPR-LYTACs demonstrated excellent targeting and effective control of local inflammation in acute GA rats.
  • Near-infrared-II fluorescence imaging confirmed specific enrichment of TPR-LYTACs at disease sites.
  • The study established a "source inhibition and microenvironment scavenging of ROS" therapeutic strategy.

Conclusions:

  • TPR-LYTACs offer a novel paradigm for precise treatment of inflammatory diseases like gouty arthritis.
  • Dual-pathway ROS regulation via nanotechnology provides a new therapeutic avenue.
  • This approach addresses the limitations of current clinical drugs in managing inflammatory conditions.