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Noncovalent Attractions in Biomolecules

Noncovalent Attractions in Biomolecules

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The Antiviral System of Bacteria and Archaea: CRISPR

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Related Experiment Video

Updated: Jun 1, 2026

Spatiotemporally Controlled Nuclear Translocation of Guests in Living Cells Using Caged Molecular Glues as Photoactivatable Tags

Spatiotemporally Controlled Nuclear Translocation of Guests in Living Cells Using Caged Molecular Glues as Photoactivatable Tags

Published on: January 17, 2019

γ-Ray Regulated Host-Guest Molecular Recognition.

Qingqing Shao^1,2, Lixia Liu¹, Jian Wang¹

¹Key Laboratory of Radiopharmaceuticals, College of Chemistry, Ministry of Education, Beijing Normal University, Beijing, China.

Angewandte Chemie (International Ed. in English)

|May 30, 2026

Summary

This summary is machine-generated.

We developed a novel gamma-irradiation-regulated host-guest system. This system enables efficient molecular recognition and hydrogel formation deep within tissues, overcoming light penetration limitations for advanced in vivo applications.

Keywords:

host‐guest recognition radiation‐responsive materials supramolecular chemistry γ‐ray irradiation

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Published on: July 18, 2013

Area of Science:

Supramolecular Chemistry
Materials Science
Radiochemistry

Background:

Light-responsive supramolecular systems offer precise molecular control but are limited by poor light penetration in vivo.
Ionizing radiation, like gamma rays, provides superior deep-tissue penetration, with established clinical uses in radiology and radiotherapy.

Purpose of the Study:

To develop a gamma-irradiation-regulated host-guest recognition system.
To enable efficient molecular recognition and material programming deep within tissues using ionizing radiation.

Main Methods:

Utilized azobenzene derivatives and macrocyclic hosts (cyclodextrins, cucurbiturils) for host-guest complexation.
Applied gamma irradiation (2 Gy) to induce cis-to-trans isomerization of azobenzene, triggering molecular recognition.
Investigated system performance through centimeter-thick porcine tissues and assessed recyclability over ten cycles.

Main Results:

Gamma rays effectively triggered azobenzene isomerization and host-guest recognition, outperforming blue light through thick tissues.
The system demonstrated excellent recyclability over ten irradiation cycles.
Gamma-ray-regulated recognition facilitated in situ hydrogelation, forming double-network hydrogels with enhanced mechanical properties (23 MPa tensile strength, 30 MJ m⁻³ toughness) and self-healing capabilities.

Conclusions:

Developed a robust gamma-irradiation-regulated host-guest system for deep-tissue molecular programming.
Demonstrated the potential of ionizing radiation to overcome limitations of light-based photoactivation in biological settings.
The system provides a versatile platform for remote control of soft material mechanics, with significant implications for in vivo applications.