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Updated: Jun 1, 2026

Microscopic Varicocelectomy under Local Anesthesia as the Treatment of Varicocele
Published on: October 25, 2024
Health-Related Quality-of-Life Improvement after Microsurgical Varicocelectomy: A Prospective Observational Study
Abdulkadir Özmez1, Feyzi Sinan Erdal2, Mehmet Özay Özgür
1Department of Urology, Haseki Training and Research Hospital, University of Health Sciences, Istanbul, Turkey, abdulkadir.ozmez@istanbul.edu.tr.
Introduction:
The aim of this study was to prospectively evaluate changes in patient-reported health-related quality of life after microsurgical subinguinal varicocelectomy using the World Health Organization Quality of Life-BREF (WHOQOL-BREF) questionnaire.
Methods:
This prospective observational study included men presenting with infertility or scrotal symptoms. Fifty patients were initially enrolled, and five with subclinical varicocele were excluded. Forty-five patients with clinically confirmed varicocele underwent microsurgical subinguinal varicocelectomy. Health-related quality of life was assessed preoperatively and at postoperative 3 months using the WHOQOL-BREF instrument. Subgroup analyses were performed according to surgical indication and clinical varicocele grade.
Results:
The mean WHOQOL-BREF total score significantly improved after surgery (61.4 ± 6.1 preoperatively vs. 70.1 ± 6.9 postoperatively; p = 0.047). Both infertility and pain/swelling groups demonstrated postoperative improvement without a significant difference between indications (p > 0.05). Grade I and II varicocele patients demonstrated significant postoperative improvement. Patients with grade III varicocele also showed postoperative score increases, although statistical significance was not reached within the early follow-up period.
Conclusion:
Microsurgical subinguinal varicocelectomy provides early improvement in patient-reported quality of life independent of presenting complaint. These findings indicate that the benefits of varicocele repair extend beyond reproductive outcomes and support incorporating patient-reported outcomes into clinical counseling and treatment decision-making.
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