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Updated: Jun 1, 2026

Electrophysiological Methods to Assess Peripheral Pain Block in an Anesthetized Rat
08:05

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Published on: November 21, 2025

Rebound Pain After Peripheral Nerve Blocks.

Burhan Dost1, Eoin Dore2, Madan Narayanan2

  • 1Department of Anesthesiology and Reanimation, Ondokuz Mayis University Faculty of Medicine, Samsun, Türkiye.

Journal of Perianesthesia Nursing : Official Journal of the American Society of Perianesthesia Nurses
|May 30, 2026
PubMed
Summary
This summary is machine-generated.

Peripheral nerve blocks offer pain relief but can cause rebound pain, a severe side effect when the block ends. Strategies like multimodal analgesia and dexamethasone may help manage this common issue.

Keywords:
nerve blockpain postoperativerebound pain

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Area of Science:

  • Anesthesiology
  • Pain Management
  • Regional Anesthesia

Background:

  • Peripheral nerve blocks are increasingly used for anesthesia and analgesia.
  • Rebound pain, a significant side effect, occurs as the block wears off, causing intense and distressing pain.
  • Up to 40% of patients may experience rebound pain after single-shot blocks, varying by surgery and patient factors.

Purpose of the Study:

  • To explore the current understanding of rebound pain after peripheral nerve blocks.
  • To examine key clinical trials investigating rebound pain.
  • To discuss practical considerations for managing rebound pain in postoperative recovery.

Main Methods:

  • Review of current evidence on peripheral nerve block rebound pain.
  • Analysis of clinical trials on preventive strategies.
  • Discussion of contributing mechanisms including inflammation and pain pathway reactivation.

Main Results:

  • Rebound pain mechanisms are complex, involving surgical trauma, inflammatory responses, and patient-specific factors.
  • Preventive strategies such as multimodal analgesia, dexamethasone (intravenous and perineural), continuous blocks, and patient education show potential benefits.
  • Variations in study designs and populations complicate definitive recommendations.

Conclusions:

  • Rebound pain is a recognized challenge following peripheral nerve blocks, impacting patient recovery.
  • Multiple strategies show promise in mitigating rebound pain, but further research is needed for standardized recommendations.
  • A multidisciplinary approach is essential for supporting patients experiencing rebound pain.