Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jun 1, 2026

Methodology for Biomimetic Chemical Neuromodulation of Rat Retinas with the Neurotransmitter Glutamate In Vitro

Methodology for Biomimetic Chemical Neuromodulation of Rat Retinas with the Neurotransmitter Glutamate In Vitro

Published on: December 19, 2017

Vision restoration: From prostheses to genetic-based brain-machine interfaces.

Ignacio Alcala¹, Erwan Desailly¹, Fabrice Arcizet¹

¹Institut de la Vision, Sorbonne Université, INSERM, CNRS, Paris, France.

Handbook of Clinical Neurology

|May 30, 2026

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Endothelial NMDA Receptor Involvement in Retinal Neurovascular Damage Following Prenatal Alcohol Exposure in a Mouse Model.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026

Same author

Clemastine fumarate promotes myelin repair in a nonhuman primate model of demyelination characterized by absent spontaneous remyelination.

Proceedings of the National Academy of Sciences of the United States of America·2026

Same author

Photovoltaic nanoassembly of nanowire arrays sensitized with colloidal nanocrystals for near-infrared retina photostimulation.

Science advances·2026

Same author

A flexible photoacoustic retinal prosthesis.

Nature communications·2025

Same author

Increased sensitivity to myopia and altered retinal ON/OFF balance in a mouse model lacking <i>Dusp4</i>.

bioRxiv : the preprint server for biology·2025

Same author

Reactivating the phototransduction cascade with a mutation agnostic gene therapy preserves vision in rod-cone dystrophies.

iScience·2025

Same journal

Preface.

Handbook of clinical neurology·2026

Same journal

Foreword.

Handbook of clinical neurology·2026

Same journal

Fundus autofluorescence imaging.

Handbook of clinical neurology·2026

Same journal

The electroretinogram as a means to study the physiology of the retina.

Handbook of clinical neurology·2026

Same journal

Adaptive optics scanning light ophthalmoscopy.

Handbook of clinical neurology·2026

Same journal

Modeling the human retina in a dish: Advances and future directions.

Handbook of clinical neurology·2026

See all related articles

New brain-machine interfaces use optogenetics and sonogenetics to restore vision. These novel approaches offer hope for blind patients and could extend to other neurological conditions.

Area of Science:

Neuroscience
Biotechnology
Medical Engineering

Background:

Restoring vision via brain-machine interfaces (BMIs) is challenging due to high pixel and refresh rate requirements for image perception.
Traditional visual prostheses use electrode arrays for retinal or cortical stimulation, enabling basic visual tasks but not face recognition.
Limitations in current visual prostheses highlight the need for advanced stimulation strategies.

Purpose of the Study:

To explore novel strategies for visual restoration using biotechnology and gene therapy.
To introduce optogenetic and sonogenetic therapies as non-contact methods for neuronal stimulation.
To assess the potential of these new BMIs for treating blindness and other neurological disorders.

Main Methods:

Optogenetic therapy modifies neurons to be light-sensitive using microbial opsins.

Keywords:

Brain–machine interfaces Optogenetics Restoring vision at retinal and cortical levels Sonogenetics Vision restoration

More Related Videos

Perspectives on Neuroscience

Perspectives on Neuroscience

Published on: July 31, 2007

Brain-Computer Interface-controlled Upper Limb Robotic System for Enhancing Daily Activities in Stroke Patients

Brain-Computer Interface-controlled Upper Limb Robotic System for Enhancing Daily Activities in Stroke Patients

Published on: April 18, 2025

Related Experiment Videos

Last Updated: Jun 1, 2026

Methodology for Biomimetic Chemical Neuromodulation of Rat Retinas with the Neurotransmitter Glutamate In Vitro

Methodology for Biomimetic Chemical Neuromodulation of Rat Retinas with the Neurotransmitter Glutamate In Vitro

Published on: December 19, 2017

Perspectives on Neuroscience

Perspectives on Neuroscience

Published on: July 31, 2007

Brain-Computer Interface-controlled Upper Limb Robotic System for Enhancing Daily Activities in Stroke Patients

Brain-Computer Interface-controlled Upper Limb Robotic System for Enhancing Daily Activities in Stroke Patients

Published on: April 18, 2025

Sonogenetic therapy engineers neurons to respond to ultrasound waves.

Evaluation of these therapies in preclinical models and, for optogenetics, in human clinical trials.

Main Results:

Optogenetic therapy has shown success in restoring vision in patients with photoreceptor degeneration.
Sonogenetic therapy has been evaluated at the cortical level in rodent models.
These methods offer a paradigm shift from electrode-based stimulation.

Conclusions:

Optogenetics and sonogenetics represent promising advancements in brain-machine interfaces for visual restoration.
These non-invasive stimulation techniques hold potential for treating blindness and other neurological conditions.
Further research and development are crucial for translating these therapies into widespread clinical applications.