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Published on: May 30, 2025
Small interfering RNA (siRNA)-based targeting breast cancer therapy
Amin Talebi1, Afshin Khorrami2, Farshid Oruji3
1Immunology Research Center, Tabriz University of Medical Sciences, Daneshghah Ave, Tabriz, Iran.
Discover Oncology
|May 31, 2026
Summary
Small interfering RNA (siRNA) therapy shows promise for breast cancer (BC) treatment by targeting cancer genes. Effective delivery systems like nanoparticles are crucial for its success and overcoming drug resistance.
Area of Science:
- Oncology
- Molecular Biology
- Nanotechnology
Background:
- Breast cancer (BC) necessitates innovative therapies due to its global health impact.
- Current treatments face challenges including drug resistance and limited efficacy.
Purpose of the Study:
- To analyze the benefits and drawbacks of siRNA therapy for breast cancer.
- To evaluate targeted delivery systems for siRNA, including liposomes and nanoparticles.
- To explore siRNA's potential in overcoming drug resistance and enhancing treatment efficacy.
Main Methods:
- Literature review of siRNA mechanisms and applications in BC.
- Analysis of nanoparticle-based delivery systems (liposomes, carbon, metal nanoparticles).
- Investigation into challenges such as delivery efficiency, immunogenicity, and off-target effects.
Main Results:
- siRNA selectively suppresses cancer-associated genes, impacting tumor initiation and progression.
- Nanoparticles show potential as effective carriers for targeted siRNA delivery.
- siRNA may help mitigate drug resistance and improve treatment outcomes.
Conclusions:
- siRNA-based therapy holds transformative potential for breast cancer treatment.
- Further research into delivery systems and safety is essential for clinical translation.
- Development of enhanced, personalized therapeutic interventions for BC is the ultimate goal.
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02:30siRNA - Small Interfering RNAs
Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the ATP-dependent...
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the ATP-dependent...
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02:30Small interfering RNAs (siRNA)
Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the ATP-dependent...
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the ATP-dependent...
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RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
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There are several types of targeted therapies against specific...
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