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[Pulmonary Arterial Hypertension Impairs Duodenal Barrier Integrity in Rats]

Shouei Ishimaru1, Satoshi Mizuno1, Tomoya Tanada1

  • 1Department of Pharmacy Practice and Sciences, School of Pharmacy and Pharmaceutical Sciences, University of Toyama.

Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan
|May 31, 2026
PubMed
Summary

Pulmonary arterial hypertension (PAH) impairs intestinal barrier function. This study found that PAH in rats significantly increased duodenal permeability, indicating a compromised gut barrier in this condition.

Keywords:
intestinal barriermonocrotalinepulmonary arterial hypertensiontight junction

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