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Uric Acid-to-Albumin Ratio Is Associated with Left Ventricular Diastolic Function in Patients with No Significant

Takafumi Kawaguchi1, Yukihiro Fukuda1, Naoya Hironobe1

  • 1Department of Cardiovascular Medicine, Hiroshima Prefectural Hospital.

International Heart Journal
|May 31, 2026
PubMed

Insights

The uric acid-to-albumin ratio (UAR) is linked to impaired left ventricular (LV) diastolic function in patients without significant heart perfusion issues. This finding suggests UAR may indicate early diastolic dysfunction detectable by gated SPECT imaging.

Area of Science:

  • Cardiology
  • Biomarkers
  • Medical Imaging

Background:

  • The uric acid-to-albumin ratio (UAR) is recognized as a marker for inflammation and cardiovascular disease prognosis.
  • The association between UAR and left ventricular (LV) diastolic function has not been previously established.

Purpose of the Study:

  • To investigate the relationship between the UAR and LV diastolic parameters.
  • To assess if UAR is associated with diastolic function in patients without significant perfusion abnormalities using gated myocardial perfusion single-photon emission computed tomography (SPECT).

Main Methods:

  • Retrospective analysis of 216 patients with preserved ejection fraction and no significant perfusion abnormalities.
  • LV diastolic parameters, including peak filling rate (PFR) and one-third mean filling rate (1/3 MFR), were measured using gated SPECT.
  • Serum uric acid and albumin levels were analyzed to calculate the UAR.

Main Results:

  • Significant inverse associations were found between UAR and both PFR (r = -0.22, P = 0.001) and 1/3 MFR (r = -0.23, P = 0.001).
  • Multivariate analysis confirmed UAR as a significant independent factor associated with PFR (β = -0.16, P = 0.024) and 1/3 MFR (β = -0.14, P = 0.047).
  • Age and LV dimensions/mass were also independently associated with diastolic parameters.

Conclusions:

  • The UAR is significantly associated with impaired LV diastolic function in patients without significant perfusion abnormalities.
  • Gated SPECT-derived diastolic parameters are influenced by the UAR, suggesting its potential role in identifying early diastolic dysfunction.

Keywords:
Myocardial imagingSerum albumin levelSerum uric acid level

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