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Updated: Jun 2, 2026

Demystifying Venous Excess Ultrasound (VExUS): Image Acquisition and Interpretation
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VEXAS Syndrome: Clues to Avoid Vexation.

Deepika Kumar1, Gauri Panse1, Christine J Ko1

  • 1Yale University, New Haven, Connecticut, USA.

Journal of Cutaneous Pathology
|May 31, 2026
PubMed
Summary
This summary is machine-generated.

VEXAS syndrome, a condition with varied symptoms, frequently presents with skin issues. This review highlights key dermatologic and dermatopathologic signs for diagnosing Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic syndrome.

Keywords:
VEXAS syndromeautoinflammatoryvasculitis

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Area of Science:

  • Rheumatology
  • Dermatology
  • Genetics

Background:

  • VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) syndrome is an emerging autoinflammatory disorder.
  • Cutaneous manifestations are reported in the majority of individuals with VEXAS syndrome.

Purpose of the Study:

  • To review the diverse clinical and dermatopathologic findings associated with VEXAS syndrome.
  • To provide guidance on recognizing VEXAS syndrome based on skin manifestations.

Main Methods:

  • Literature review of VEXAS syndrome cases with a focus on dermatologic and dermatopathologic features.
  • Synthesis of clinical presentation, histopathology, and diagnostic criteria.

Main Results:

  • VEXAS syndrome presents with a wide spectrum of skin findings.
  • Dermatologic clues are crucial for early identification and diagnosis.

Conclusions:

  • Dermatologists play a key role in the diagnosis of VEXAS syndrome.
  • Recognition of specific cutaneous and dermatopathologic findings can aid in timely diagnosis and management.