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Updated: Jun 2, 2026
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A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting
Published on: January 12, 2018
Intersectionality of early developmental risks and resilience after preterm birth.
Julia Jäkel1,2,3, Janika Ludwig4, Britta Hüning4
1Klinik für Kinderheilkunde I, University Hospital Essen, University Duisburg-Essen, Essen, Germany. julia.jaekel@uk-essen.de.
Molecular and Cellular Pediatrics
|May 31, 2026
Summary
Early life microbiome and brain development are crucial. Preterm infants face challenges affecting the gut-brain axis, highlighting the need for research into modifiable factors for better outcomes.
Area of Science:
- Developmental biology
- Neuroscience
- Microbiome research
Background:
- The period from conception through preschool is critical for microbiome and brain development.
- Modifiable factors like delivery mode, antibiotics, nutrition, breastfeeding, and caregiving influence the gut-brain axis.
- Infants born preterm (<37 weeks gestation) experience challenges impacting gut microbiome and neurobehavioral development, often worsened by social stress.
Purpose of the Study:
- To understand the complex mechanisms shaping the gut-brain axis in early development.
- To identify modifiable protective factors for preventing adverse outcomes after preterm birth.
- To address knowledge gaps in the interaction between gut, brain, and behavioral development over time.
Main Methods:
- The study emphasizes the need for translational research on the gut-brain axis after preterm birth.
- Future studies should incorporate social factors (e.g., education, immigrant background) into sampling.
- Investigate how interventions can optimize long-term outcomes by considering microbiome modifications.
Main Results:
- A significant knowledge gap exists regarding the interplay of gut, brain, and behavioral development.
- Social and modifiable factors are key drivers of the gut-brain axis interaction.
- Preterm birth poses unique challenges to the developing gut microbiome and neurobehavioral trajectories.
Conclusions:
- Translational research is critically needed to understand the gut-brain axis in preterm infants.
- Identifying susceptible populations and effective interventions is key for optimizing long-term outcomes.
- Harnessing modifiable factors offers potential for targeted prevention strategies.
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