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Updated: Jun 2, 2026

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68Ga-FAPI PET/CT safely detects multifocal endometriosis: a case report.

Ghasemali Divband1, Arezoo Milani2, Masoume Chehrara3

  • 1Jam Nuclear Medicine Center, Jam Hospital, Tehran, Iran.

EJNMMI Reports
|May 31, 2026
PubMed
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This summary is machine-generated.

New molecular imaging with 68Ga-FAPI-46 PET/CT successfully detected hidden multifocal endometriosis missed by conventional methods. This safe imaging technique shows promise for improved diagnosis and surgical planning in women with endometriosis.

Area of Science:

  • Molecular imaging
  • Nuclear medicine
  • Gynecologic imaging

Background:

  • Endometriosis diagnosis is challenging, often missing multifocal lesions with standard imaging.
  • Fibroblast Activation Protein (FAP) is a target for molecular imaging in fibrotic conditions.

Purpose of the Study:

  • To evaluate the efficacy of 68Ga-FAPI-46 PET/CT in detecting multifocal endometriosis.
  • To assess the safety and diagnostic accuracy of this novel imaging modality compared to conventional methods.

Main Methods:

  • A case study involving a 28-year-old woman with suspected endometriosis.
  • Comparison of transvaginal ultrasound (TVS), pelvic MRI, and 68Ga-FAPI-46 PET/CT.
  • Radiation dosimetry using Monte Carlo simulations to determine organ doses.
Keywords:
68Ga-FAPIEndometriosisFibroblast activation proteinMolecular imagingPET/CT

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Main Results:

  • 68Ga-FAPI-46 PET/CT identified a known ovarian endometrioma and two additional, previously undetected nodules.
  • Conventional imaging (TVS, MRI) missed these additional lesions.
  • Surgical pathology confirmed multifocal endometriosis, validating PET/CT findings. Low radiation dose confirmed safety.

Conclusions:

  • 68Ga-FAPI-46 PET/CT is a safe and effective tool for detecting occult endometriosis.
  • This molecular imaging technique can reveal lesions missed by standard ultrasound and MRI.
  • Further research with larger cohorts is warranted to establish its role in routine clinical practice.