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Published on: June 10, 2025

Prognostic Value of HALP and PNI Scores in ICU Patients with Decompensated Heart Failure

Esra Polat, Sukru Ciris1, Sedat Sakalli1

  • 1Department of Cardiology, Gaziantep City Hospital, Gaziantep, Turkiye.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
|June 1, 2026
PubMed

Insights

Nutritional status, assessed by the Haemoglobin, Albumin, Lymphocyte, and Platelet (HALP) score and Prognostic Nutritional Index (PNI), is linked to mortality in heart failure patients. These scores offer prognostic insights but are not independent predictors.

Area of Science:

  • Cardiology
  • Critical Care Medicine
  • Nutritional Science

Background:

  • Heart failure (HF) is a complex condition with significant mortality.
  • Nutritional status is increasingly recognized as a crucial factor influencing HF prognosis.
  • The Haemoglobin, Albumin, Lymphocyte, and Platelet (HALP) score and Prognostic Nutritional Index (PNI) are potential indicators of nutritional status.

Purpose of the Study:

  • To investigate the association between mortality and nutritional status in heart failure (HF) patients.
  • To evaluate the predictive value of the HALP score and PNI for mortality in decompensated HF.
  • To determine if HALP and PNI can serve as supportive prognostic indicators.

Main Methods:

  • A descriptive analytical study involving 111 patients with decompensated HF admitted to a coronary care unit.
  • Calculation of HALP and PNI scores based on recorded haematological and biochemical parameters.
  • Statistical analysis including Mann-Whitney U test, Pearson chi-square test, Fisher's exact test, and ROC curve analysis to assess mortality prediction.

Main Results:

  • Both HALP (AUC = 0.700) and PNI (AUC = 0.770) showed significant discriminative ability for mortality in HF patients.
  • Optimal cut-off values were identified as ≤18.09 for HALP and ≤41.30 for PNI.
  • HALP and PNI scores demonstrated a significant predictive value for mortality.

Conclusions:

  • The HALP and PNI scores, reflecting nutritional status, are associated with mortality in intensive care unit (ICU) patients with decompensated HF.
  • These scores may offer supportive prognostic information for HF patients.
  • However, HALP and PNI were not found to be independent predictors of mortality in multivariate analysis.
Abstract

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