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Updated: Jun 2, 2026

Folding and Characterization of a Bio-responsive Robot from DNA Origami
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Molecular Engineering of the Nano-Bio Interface for Programmable and Precision Protein Delivery.

Tianyu Ma1,2, Rui Yao1,2, Qingyan Zhang1,2

  • 1Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China.

Advanced Materials (Deerfield Beach, Fla.)
|June 1, 2026
PubMed
Summary

Nanoparticle engineering enhances protein drug delivery by overcoming cell membrane barriers. This review explores advanced nanoplatforms for targeted protein delivery, improving therapeutic efficacy for complex diseases.

Keywords:
drug deliverygenome editingin vivolipid based nanoparticlesmetal‐organic frameworkmolecular engineeringnanotechnologyprotein degradationsupramolecular chemistrytissue specific

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Molecular Medicine

Background:

  • Protein therapeutics offer high specificity but face challenges with structural instability and cell entry.
  • Cellular membrane impermeability limits the therapeutic potential of protein-based drugs.
  • Effective delivery systems are crucial for harnessing the power of protein therapeutics.

Purpose of the Study:

  • To review advancements in nanoparticle-mediated protein delivery systems.
  • To highlight strategies for overcoming physiological barriers and enhancing protein therapeutic efficacy.
  • To discuss future directions in nanocarrier design and clinical translation.

Main Methods:

  • Systematic review of diverse nanoplatforms (lipid nanoparticles, polymeric assemblies, porous nanomaterials, supramolecular architectures).
  • Analysis of molecular engineering strategies for nano-bio interface control.
  • Evaluation of techniques for protein encapsulation, targeting, and endosomal escape.

Main Results:

  • Tailored nanocarrier compositions and structures effectively navigate physiological barriers.
  • Innovations in protein encapsulation and organ-selective targeting improve therapeutic outcomes.
  • Strategies for endosomal escape are critical for cytosolic delivery and maximizing potency.

Conclusions:

  • Nanoparticle-mediated delivery represents a paradigm shift for protein therapeutics.
  • Overcoming delivery challenges is key to unlocking the full potential of protein-based medicines.
  • Future research should focus on AI-driven discovery, biosafety, and clinical translation.