Related Experiment Video
Updated: Jun 2, 2026
07:39
Co-culture of Glutamatergic Neurons and Pediatric High-Grade Glioma Cells Into Microfluidic Devices to Assess Electrical Interactions
Published on: November 17, 2021
C1QL1: A Long-range Signal Orchestrating Glioma Connectivity and Synaptic Remodeling
1Cancer Center and Neuroscience Division, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.
Cancer Discovery
|June 1, 2026
Abstract
None:
Glioblastoma (GBM) cells secrete C1QL1, which binds BAI3 on nearby neurons and tumor cells to activate RAC1, promoting tumor microtube growth, malignant synapse formation, and remodeling of normal synapses. Blocking RAC1 with a targeted inhibitor disrupts this process and may help prevent GBM recurrence. See related article by Ding et al., p. 1176.
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