Related Experiment Video

Updated: Jun 2, 2026

An Orthotopic Murine Model of Human Prostate Cancer Metastasis
06:48

An Orthotopic Murine Model of Human Prostate Cancer Metastasis

Published on: September 18, 2013

MITF Gain-of-Function Mutation in Metastatic Prostate Cancer: A Rare Finding With Potential Therapeutic Significance

Paul J Pecorin1, Nyembezi Dhliwayo2, Matthew Demetrious3

  • 1Division of General Internal Medicine, Department of Medicine, Rush University Medical Center, Chicago, Illinois, USA.

Cancer Reports (Hoboken, N.J.)
|June 1, 2026
PubMed
Abstract

Insights

The microphthalmia-associated transcription factor (MITF) E318K mutation, previously seen in other cancers, was found in a prostate cancer patient. This discovery suggests MITF may play a role in aggressive prostate tumor development.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Prostate cancer is a leading cause of male cancer mortality, especially aggressive forms.
  • Common genetic alterations in aggressive prostate tumors include TP53, RB1, and PTEN.
  • The role of microphthalmia-associated transcription factor (MITF) in prostate cancer is not well-defined.

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