Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
Dosage Regimens: Designs and Approaches01:28

Dosage Regimens: Designs and Approaches

Designing a dosage regimen, which refers to the manner of drug administration, is a complex process involving the selection of drug dose, route, and frequency. This process is underpinned by pharmacokinetic parameters derived from tests and population averages. These parameters are then tailored to patient-specific variables such as diagnosis, demographics, and allergy status. Once therapy commences, therapeutic response monitoring is critical and achieved through clinical and physical...
Dose Size and Dosing Frequency: Determination Methods01:21

Dose Size and Dosing Frequency: Determination Methods

Determining the optimal dose size and dosing frequency in pharmacotherapy is crucial for achieving therapeutic effectiveness while minimizing adverse effects. This article explores the methodologies employed in determining these parameters, focusing on their significance and interplay to tailor dosing regimens.Dose Size: Dose size refers to the amount of a drug administered in a single dose. It is determined based on the drug's pharmacodynamics and pharmacokinetics properties and...
Dosage Regimen: Individualization01:24

Dosage Regimen: Individualization

Individualization in dosing regimens is the customization of medication doses for individual patients. Its necessity arises from the goal of maximizing therapeutic benefits while minimizing risks. This approach is pivotal because human responses to drugs can vary widely; what is effective for one person may be inadequate or excessive for another. Interpatient (intersubject) variability refers to differences in drug responses between individuals, while intrapatient (intrasubject) variability...
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Diagnostic Accuracy of Bayley III Screening Tool to Detect Developmental Delay in Moderate to High-Risk Indian Preterm Children.

Indian journal of pediatrics·2023
Same author

Characteristics and treatment analysis of young acute coronary syndrome patients in a tertiary care hospital: A cross-sectional retrospective study.

Health science reports·2023
Same author

Level of adherence to anti-tubercular treatment among drug-sensitive tuberculosis patients on a newly introduced daily dose regimen in South India: A cross-sectional study.

Tropical medicine & international health : TM & IH·2022
Same author

Effect of L-Carnosine on Children with ADHD.

Indian journal of pediatrics·2022
Same author

Toxicity profile, adverse drug reactions and drug-drug interactions among geriatric cancer patients under metronomic chemotherapy in a South Indian tertiary care hospital.

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners·2022
Same author

Effect of L-Carnosine in children with autism spectrum disorders: a systematic review and meta-analysis of randomised controlled trials.

Amino acids·2021
Same journal

Toll-Like Receptor-Mediated Neuroinflammation and Its Role in Neurocognitive Functions.

Current reviews in clinical and experimental pharmacology·2026
Same journal

Microbiome Drug Interactions in Cancer Pharmacology: Mechanisms and Therapeutic Opportunities.

Current reviews in clinical and experimental pharmacology·2026
Same journal

Exploring TRPM7 Channel-Kinase for Disease Modulation: A Translational Approach.

Current reviews in clinical and experimental pharmacology·2026
Same journal

Pharmacological Perspectives on Curcumin in Osteomyelitis: Molecular Mechanisms, Antibacterial Synergy, and Bone-Regenerative Potential.

Current reviews in clinical and experimental pharmacology·2026
Same journal

Role of Lysosomal Genes for Parkinson's Pathogenesis: Insights from Molecular Mechanism to Therapeutic Strategies.

Current reviews in clinical and experimental pharmacology·2026
Same journal

Mechanistic Insights and Therapeutic Potential of MCC950 as a NLRP3 Inflammasome Inhibitor in Multiple Sclerosis: A Narrative Review.

Current reviews in clinical and experimental pharmacology·2026
See all related articles

Related Experiment Video

Updated: Jun 2, 2026

Disposable Dosators Intended for Dry Powder Delivery to Mice
04:59

Disposable Dosators Intended for Dry Powder Delivery to Mice

Published on: August 18, 2023

Model-Informed Precision Dosing in Pediatrics: Current Practices, Opportunities, and Challenges.

Rohith Anandan Prabakar1, Abilash Reddybathini2, Chandramouli Radhakrishnan3

  • 1SRM College of Pharmacy, Faculty of Medicine and Health Sciences, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu, Tamil Nadu, India.

Current Reviews in Clinical and Experimental Pharmacology
|June 1, 2026
PubMed
Summary
This summary is machine-generated.

Optimizing drug doses for children requires understanding age-related physiological changes. Model-Informed Precision Dosing (MIPD) using advanced modeling strategies like Population Pharmacokinetic (PopPK) and Physiologically Based Pharmacokinetic (PBPK) shows promise for safer and more effective pediatric medication.

Keywords:
Pediatric pharmacokineticsartificial intelligence (AI)bayesian forecastingmachine learning (ML).physiologically based pharmacokinetic (PBPK) modelingpopulation pharmacokinetic (PopPK) modeling

More Related Videos

Use of Micropipette-Guided Drug Administration as an Alternative Method to Oral Gavage in Rodent Models
02:44

Use of Micropipette-Guided Drug Administration as an Alternative Method to Oral Gavage in Rodent Models

Published on: July 26, 2024

Related Experiment Videos

Last Updated: Jun 2, 2026

Disposable Dosators Intended for Dry Powder Delivery to Mice
04:59

Disposable Dosators Intended for Dry Powder Delivery to Mice

Published on: August 18, 2023

Use of Micropipette-Guided Drug Administration as an Alternative Method to Oral Gavage in Rodent Models
02:44

Use of Micropipette-Guided Drug Administration as an Alternative Method to Oral Gavage in Rodent Models

Published on: July 26, 2024

Area of Science:

  • Pharmacology
  • Pediatric Medicine
  • Computational Biology

Background:

  • Children exhibit significant age-dependent physiological variations impacting drug behavior.
  • Traditional dosing methods often fail to account for these pediatric-specific pharmacokinetic differences.
  • Optimizing pediatric drug therapy necessitates specialized approaches to ensure efficacy and safety.

Purpose of the Study:

  • To review pharmacokinetic differences between pediatric and adult populations.
  • To compare traditional dosing strategies with advanced Model-Informed Precision Dosing (MIPD) approaches.
  • To explore the role of Population Pharmacokinetic (PopPK) and Physiologically Based Pharmacokinetic (PBPK) modeling in pediatric drug development.

Main Methods:

  • Literature review of pediatric pharmacokinetics and dosing strategies.
  • Analysis of Population Pharmacokinetic (PopPK) and Physiologically Based Pharmacokinetic (PBPK) modeling techniques.
  • Examination of recent advancements including Bayesian forecasting, AI, and machine learning in pharmacometrics.

Main Results:

  • MIPD, utilizing PopPK and PBPK models, offers improved accuracy over traditional methods.
  • Bayesian forecasting and AI/ML integration enhance dosing precision and clinical decision-making.
  • Current regulatory frameworks are evolving to incorporate advanced pharmacometric approaches.

Conclusions:

  • Model-based precision dosing is crucial for optimizing pediatric medication efficacy and safety.
  • Continued development and integration of advanced modeling techniques are essential.
  • Addressing technical, logistical, and regulatory challenges will facilitate wider adoption of MIPD in pediatrics.